Tag: M.W:200-300

Formula: C5H10Br2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about N-spirocyclic ammonium-functionalized graphene oxide-based anion exchange membrane for fuel cells. Author is Long, Chuan; Lu, Chuanrui; Li, Yunxi; Wang, Zhihua; Zhu, Hong.

Graphene oxide (GO) is a potential material in the electrode and membrane of polymer electrolyte membrane fuel cells due to its unique structure and various oxygen-containing functional groups. A class of three-layered GO/poly(phenylene oxide) for AEMs was prepared in this work. GO was functionalized with highly stable 6-azonia-spiro [5.5]undecane groups and used as a fast hydroxide conductor, named ASU-GO. Functionalized by N-spirocyclic cations, poly (phenylene oxide) (PIPPO) was then combined with ASU-GO and GO to fabricate the ASU-GO/PIPPO and GO/PIPPO. Notably, the maximum hydroxide conductivity of the ASU-GO/PIPPO was 73.7 mS cm-1 at 80 °C, which was 3 times higher than that of the GO/PIPPO. The enhancement in hydroxide conductivity was due to the changes in the hydroxide transport mechanism and the poor stacked structure of the ASU-GO layer. Only 10.8% drops in hydroxide conductivity of ASU-GP/PIPPO after the alk. test (1 M KOH at 80 °C for 700 h). Furthermore, the ASU-GO/PIPPO-50 membrane showed a maximum peak power d. of 102 mW cm-2, demonstrating the prepared membrane was promising in the AEM applications.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 2-Chloro-5-pyridinesulfonyl chloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloro-5-pyridinesulfonyl chloride, is researched, Molecular C5H3Cl2NO2S, CAS is 6684-39-5, about Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 3. Structure-Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N’-arylpiperazine Series. Author is Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St. Jean, David J..

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small mol. to its endogenous inhibitor, glucokinase regulatory protein (GKRP). These initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (I, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound I bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives II and III possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

I hope my short article helps more people learn about this compound(2-Chloro-5-pyridinesulfonyl chloride)Safety of 2-Chloro-5-pyridinesulfonyl chloride. Apart from the compound(6684-39-5), you can read my other articles to know other related compounds.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Molecules called Design, synthesis, and antitumor activity of a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones, Author is Xing, Naiguo; Chen, Chen; Zhong, Qiu; Zheng, Shilong; Wang, Guangdi; He, Ling, which mentions a compound: 6684-39-5, SMILESS is ClC1=NC=C(C=C1)[S](=O)(=O)Cl, Molecular C5H3Cl2NO2S, Recommanded Product: 2-Chloro-5-pyridinesulfonyl chloride.

Based on benzenesulfonylazaspirodienone (HL-X9) identified in the previous work, the lead compound for better efficacy is optimized, thereby synthesizing a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-one derivatives such as I through a key step of metal-catalyzed cascade cyclization. The preliminary antiproliferative tests have shown that the anticancer activities of acetyl-protected mannose-linked sulfonylazaspirodienone derivatives have been greatly improved. Among them, II is the most potent derivative, with IC50 values of 0.17μM, 0.05μM, and 0.07μM for A549, MDA-MB-231, and HeLa cell lines, resp. Flow cytometry anal. shows that II arrests MDA-MB-231 cells in the G2/M phase and has a certain effect on the apoptosis of MDA-MB-231 cells. In addition, the acute toxicity of II was lower than that of adriamycin.

I hope my short article helps more people learn about this compound(2-Chloro-5-pyridinesulfonyl chloride)Recommanded Product: 2-Chloro-5-pyridinesulfonyl chloride. Apart from the compound(6684-39-5), you can read my other articles to know other related compounds.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Russian Journal of Organic Chemistry called The First Analog of Pyrimidine Nucleosides with Two Nucleobases and Two D-Ribofuranose Residues, Author is Andreeva, O. V.; Saifina, L. F.; Belenok, M. G.; Semenov, V. E.; Kataev, V. E., which mentions a compound: 111-24-0, SMILESS is BrCCCCCBr, Molecular C5H10Br2, SDS of cas: 111-24-0.

The reaction of 1,5-bis[1-(prop-2-yn-1-yl)uracil-3-yl]pentane with 2′,3′,5′-tri-O-acetyl-β-D-ribofuranosylazide followed by removing of acetyl protective groups with a solution of sodium methylate in methanol afforded 1,5-bis{[1-methyl(β-D-ribofuranosyl)-1H-1,2,3-triazole-4-yl]uracil-3-yl}pentane which is the first analog of pyrimidine nucleosides with two nucleobases and two D-ribofuranose residues.

I hope my short article helps more people learn about this compound(1,5-Dibromopentane)SDS of cas: 111-24-0. Apart from the compound(111-24-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 111-24-0, is researched, SMILESS is BrCCCCCBr, Molecular C5H10Br2Journal, Article, Physical Chemistry Chemical Physics called The role of conformational heterogeneity in the excited state dynamics of linked diketopyrrolopyrrole dimers, Author is Bradley, Siobhan J.; Chi, Ming; White, Jonathan M.; Hall, Christopher R.; Goerigk, Lars; Smith, Trevor A.; Ghiggino, Kenneth P., the main research direction is diketopyrrolopyrrole preparation conformation fluorescence excited state electronn transfer.SDS of cas: 111-24-0.

Diketopyrrolopyrrole (DPP) derivatives have been proposed for both singlet fission and energy upconversion as they meet the energetic requirements and exhibit superior photostability compared to many other chromophores. In this study, both time-resolved electronic and IR spectroscopy have been applied to investigate excited state relaxation processes competing with fission in dimers of DPP derivatives with varying linker structures. A charge-separated (CS) state is shown to be an important intermediate with dynamics that are both solvent and linker dependent. The CS state is found for a subset of the total population of excited mols. and it is proposed that CS state formation requires suitably aligned dimers within a broader distribution of conformations available in solution No long-lived triplet signatures indicative of singlet fission were detected, with the CS state likely acting as an alternative relaxation pathway for the excitation energy. This study provides insight into the role of mol. conformation in determining excited state relaxation pathways in DPP dimer systems.

Here is just a brief introduction to this compound(111-24-0)SDS of cas: 111-24-0, more information about the compound(1,5-Dibromopentane) is in the article, you can click the link below.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,5-Dibromopentane( cas:111-24-0 ) is researched.SDS of cas: 111-24-0.Pham, Thanh Huong; Allushi, Andrit; Olsson, Joel S.; Jannasch, Patric published the article 《Rational molecular design of anion exchange membranes functionalized with alicyclic quaternary ammonium cations》 about this compound( cas:111-24-0 ) in Polymer Chemistry. Keywords: ammonium cation rational mol anion exchange membrane alicyclic quaternary. Let’s learn more about this compound (cas:111-24-0).

High alk. stability is critical for polymeric anion exchange membranes (AEMs) and ionomers for use in alk. electrochem. energy conversion and storage devices such as fuel cells, electrolyzer cells and advanced batteries. Here, we have prepared and studied ether-free polyfluorenes tethered with N,N-dimethylpiperidinium (DMP) and 6-azonia-spiro[5.5]undecane (ASU) cations, resp., attached through heteroatom-free alkyl spacers. By employing alkyl-alkyl Suzuki cross-coupling, these alicyclic quaternary ammonium cations are attached at the 4-position to impede ionic loss. Thus, all the β-hydrogens sensitive to elimination reactions are placed in strain-free rings able to fully relax by the spacer flexibility. Consequently, the AEM carrying DMP cations shows a very high alk. and thermal stability, retaining more than 91% of the cations after 2400 h immersion in 2 M NaOH at 90 °C. Compared with corresponding AEM functionalized with N-alkyl-N-methylpiperidinium (AMP) cations [conventionally tethered via the 1(N)-position], the ionic loss by β-elimination is successfully reduced by up to 92%. The AEM functionalized with DMP also reaches a high hydroxide conductivity of 124 mS cm-1 at 80 °C. Consequently, tethering piperidine-based cations via the 4-position instead of the 1(N)-position results in AEMs with substantially improved thermal and alk. stability, combined with high hydroxide conductivity

Here is just a brief introduction to this compound(111-24-0)SDS of cas: 111-24-0, more information about the compound(1,5-Dibromopentane) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 111-24-0, is researched, SMILESS is BrCCCCCBr, Molecular C5H10Br2Journal, International Journal of Hydrogen Energy called High chemical stability anion exchange membrane based on poly(aryl piperidinium): Effect of monomer configuration on membrane properties, Author is Long, Chuan; Wang, Zhihua; Zhu, Hong, the main research direction is polytriphenyl piperidine based anion exchange membrane preparation.SDS of cas: 111-24-0.

In recent years, ether-free polyaryl polymers prepared by superacid-catalyzed Friedel-Crafts polymerization have attracted great research interest in the development of anion exchange membranes(AEMs) due to their high alkali resistance and simple synthesis methods. However, the selection of monomers for high-performance polymer backbone and the relationship between polymer structure construction and properties need further investigated. Herein, a series of free-ether poly(aryl piperidinium) (PAP) with different polymer backbone steric construction were synthesized as stable anion exchange membranes. Meta-terphenyl, p-terphenyl and diphenyl-terphenyl copolymer were chosen as monomers to regulate the spatial arrangement of the polymer backbone, which tethered with stable piperidinium cation to improve the chem. stability. In addition, a multi-cation crosslinking strategy has been applied to improve ion conductivity and mech. stability of AEMs, and further compared with the performance of uncrosslinked AEMs. The properties of the resulting AEMs were investigated and correlated with their polymer structure. In particular, m-terphenyl based AEMs exhibited better dimensional stability and the highest hydroxide conductivity of 144.2 mS/cm at 80°C than other membranes, which can be attributed to their advantages of polymer backbone arrangement. Furthermore, the hydroxide conductivity of the prepared AEMs remains 80%-90% after treated by 2 M NaOH for 1600 h, exhibiting excellent alk. stability. The single cell test of m-PTP-20Q4 exhibits a maximum power d. of 239 mW/cm2 at 80°C. Hence, the results may guide the selection of polymer monomers to improve performance and alk. durability for anion exchange membranes.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Kulaga, Damian; Jaskowska, Jolanta; Satala, Grzegorz published an article about the compound: 1,5-Dibromopentane( cas:111-24-0,SMILESS:BrCCCCCBr ).Product Details of 111-24-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:111-24-0) through the article.

Schizophrenia and depression are diseases that significantly impede human functioning in society. Current antidepressant drugs are not fully effective. According to literature data, the effect on D2R or 5-HT1AR can effectively reduce the symptoms of depression or schizophrenia. Recent research hypothetized that the synergism of both of these receptors can improve the effectiveness of therapy. Ipsapirone, a representative of long-chain arylpiperazines, is a known 5-HT1AR ligand that has antidepressant effect. This compound has no affinity for the D2R. Bearing in mind, we decided to design ligands with improved affinity to D2R and confirmed that in some cases elongation of the carbon linker or arylpiperazine exchange may have beneficial influence on the binding to D2R and 5-HT1AR. Four groups of ligands being ipsapirone analogs with Bu, pentyl, hexyl and stiffened xylene chains were designed. All compounds were obtained in solvent-free reactions supported by a microwave irradiation with an efficiency mainly above 60%. All ligands containing 1-(2-pyrimidinyl)piperazine exhibited high affinity to 5-HT1AR. In this case, chem. modifications within the chain did not affect the affinity to D2R. In the case of ligands containing 1-phenylpiperazine, 1-(3-trifluoromethylphenyl)piperazine, 1-(1-naphthyl)piperazine, and 1-(4-chlorophenyl)piperazine, elongation of carbon linker increases of affinity to D2R. For ligands containing 1- (2-pyridyl) piperazine, and 1-(2,3-dichlorophenyl)piperazine, we observed an opposite effect. For ligands containing 1-phenylpiperazine, 1-(2-methoxyphenyl)piperazine and 1-(2-pyridyl)piperazine, chain elongation had no effect on 5-HT1AR binding. In turn of ligands containing 1-(3-trifluoromethylphenyl)piperazine and 1- (2,3-dichlorophenyl)piperazine, we observed that elongation of carbon linker has a pos. influence to 5-HT1AR. Mol. modeling was used to support the SAR study.

I hope my short article helps more people learn about this compound(1,5-Dibromopentane)Product Details of 111-24-0. Apart from the compound(111-24-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C5H10Br2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about 3,28-Diacetoxylup-20(29)-ene-30-oic acid and its ω-bromoalkyl esters. Author is Ponomaryov, D. V.; Grigor’eva, L. R.; Nemtarev, A. V.; Tsepaeva, O. V.; Mironov, V. F.; Gnezdilov, O. I.; Antipin, I. S..

A convenient procedure was developed for the synthesis of 3β,28-diacetoxylup-20(29)-en-30-oic acid I (R = H) via oxidation of 3β,28-di-O-acetylbetulin with selenium dioxide in aqueous ethanol on heating, followed by oxidation of 3β,28-diacetoxylup-20(29)-en-30-al thus formed with sodium chlorite in tert-Bu alc. The alkylation of the acid with 1,3-dibrompropane and 1,5-dibromopentane in boiling acetonitrile in the presence of potassium carbonate afforded the corresponding ω-bromoalkyl esters I [R = (CH2)3Br, (CH2)5Br] in high yields.

Compound(111-24-0)Electric Literature of C5H10Br2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1,5-Dibromopentane), if you are interested, you can check out my other related articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ionic polyureas-a novel subclass of poly(ionic liquid)s for CO2 capture》. Authors are Morozova, Sofia M.; Lozinskaya, Elena I.; Sardon, Haritz; Suarez-Garcia, Fabian; Vlasov, Petr S.; Vaudemont, Regis; Vygodskii, Yakov S.; Shaplov, Alexander S..The article about the compound:1,5-Dibromopentanecas:111-24-0,SMILESS:BrCCCCCBr).SDS of cas: 111-24-0. Through the article, more information about this compound (cas:111-24-0) is conveyed.

The growing concern for climate change and global warming has given rise to investigations in various research fields, including one particular area dedicated to the creation of solid sorbents for efficient CO2 capture. In this work, a new family of poly(ionic liquid)s (PILs) comprising cationic polyureas (PURs) with tetrafluoroborate (BF4) anions has been synthesized. Condensation of various diisocyanates with novel ionic diamines and subsequent ion metathesis reaction resulted in high molar mass ionic PURs (Mw = 12 ÷ 173 x 103 g/mol) with high thermal stability (up to 260 °C), glass transition temperatures in the range of 153-286 °C and remarkable CO2 capture (10.5-24.8 mg/g at 0 °C and 1 bar). The CO2 sorption was found to be dependent on the nature of the cation and structure of the diisocyanate. The highest sorption was demonstrated by tetrafluoroborate PUR based on 4,4′-methylene-bis(cyclohexyl isocyanate) diisocyanate and aromatic diamine bearing quinuclidinium cation (24.8 mg/g at 0 °C and 1 bar). It is hoped that the present study will inspire novel design strategies for improving the sorption properties of PILs and the creation of novel effective CO2 sorbents.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis