Tag: M.W:200-300

Computed Properties of C5H10Br2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Study of the interaction between ninhydrin and chromium(III)-amino acid in an aqueous-micellar system: Influence of gemini surfactant micelles. Author is Kumar, Dileep; Abdul Rub, Malik.

Chromium(III)-amino acid ([Cr(III)-His]2+) and ninhydrin in an aqueous-micellar system were combined in acetate buffer at 353 K and analyzed by UV-vis spectroscopy. Dimeric geminis (16-s-16, s, spacer, = 4 to 6) were chosen as a surfactant and their influence on the reaction rate was determined To show this behavior of gemini surfactants on rate constant (kψ), kψ was plotted against different surfactant concentrations kψ increases with increasing [16-s-16] (at concentrations lesser than their cmc values, segment I) and leveling-off regions attain (concentration upto 400 × 10-5 mol dm-3, segment II). Later, [16-s-16] generates a third region of increasing kψ at higher [16-s-16] ([16-s-16] > 400 × 10-5 mol dm-3, segment III). The uncommon plot behavior of kψ vs. [16-s-16] was revealed, effectively, by utilizing a pseudo-phase model of micellar activity. Critical micellar concentration of pure gemini surfactants, as well as their mixed solution with reactants, was determined by conductometry. Based on the data, various thermodn. parameters and binding constants were calculated under different exptl. reaction conditions.

Here is a brief introduction to this compound(111-24-0)Computed Properties of C5H10Br2, if you want to know about other compounds related to this compound(111-24-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: 6684-39-5. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloro-5-pyridinesulfonyl chloride, is researched, Molecular C5H3Cl2NO2S, CAS is 6684-39-5, about Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents. Author is Song, Junrong; Lan, Junjie; Chen, Chao; Hu, Shengcao; Song, Jialei; Liu, Wulin; Zeng, Xueyi; Lou, Huayong; Ben-David, Yaacov; Pan, Weidong.

Twenty-four 14-sulfonamide-tetrandrine derivatives as potential anti-cancer agents were synthesized. The synthetic derivatives were investigated for their cytotoxic activity against human cancer cell lines MDA-MB-231, PC3, WM9, HEL and K562. Initially, the IC50 values (50% inhibitory concentrations) of all of the compounds were determined These derivatives exhibited potent, but distinct, inhibitory effects on the above-mentioned cell lines. Among them, compound 23, which was modified with a 2-naphthalenesulfonyl group at the 14-amino position, showed impressive inhibition of all five cancer cell lines, and especially of MDA-MB-231 cells with an IC50 value of 1.18 ± 0.14 μM. Further mechanism exploration showed that 23 induced potent apoptotic cell death on MDA-MB-231 cancer cells in a concentration-dependent manner. The results revealed that 23 might be a potential anti-cancer drug candidate.

Here is a brief introduction to this compound(6684-39-5)HPLC of Formula: 6684-39-5, if you want to know about other compounds related to this compound(6684-39-5), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: C14H19FeN, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 31886-57-4, Name is (S)-N,N-Dimethyl-1-ferrocenylethylamine,belongs to chiral-nitrogen-ligands compounds, now introducing its new discovery.

The present invention provides a metallocenyl compound of formula (I). Ra, Rb, Rc, Rd, Re, Rf, M, m, n, j, k, Y and Z and * are as described in the specification. The invention also provides a process for the preparation of the complexes, a process for increasing the optical purity of a compound of formula (II) and a process for the asymmetric transfer hydrogenation (ATH) of a metallocenyl compound of formula (V) to a metallocenyl compound of formula (IV).

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. HPLC of Formula: C14H19FeN, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 31886-57-4, in my other articles.

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of 492-08-0, Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 492-08-0, Name is (+)-Sparteine,belongs to chiral-nitrogen-ligands compounds, now introducing its new discovery.

The present invention relates to processes for preparing enantiopure Lupanine and Sparteine.

Keep reading other articles of 492-08-0! Don’t worry, you don’t need a PhD in chemistry to understand the explanations!

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. Computed Properties of C14H19FeN, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 31886-57-4, name is (S)-N,N-Dimethyl-1-ferrocenylethylamine. In an article，Which mentioned a new discovery about 31886-57-4

Treatment of the alpha-dimethylamino[3]ferrocenophane system 3 with methyl iodide followed by dimesitylphosphine (Mes2PH) gave the alpha-(dimesitylphosphino)[3]ferrocenophane 5. This forms a frustrated Lewis pair [5/8] with B(C6F5)3 (8) that rapidly reacts with dihydrogen under ambient conditions to probably give the phosphonium cation/hydrido borate anion salt [5-H+/H-8-]. This, however, is unstable under the applied reaction conditions with regard to replacement of the newly formed phosphonium leaving group at the ferrocenophane a-position for hydride from the [HB(C6F5)3 -] counteranion to eventually yield the unfunctionalized [3]ferrocenophane product (10) and Mes2PH· B(C 6F5)3 (11) – both characterized by independent syntheses. Analogously, Ugi’s amine (6) was converted to (1-(dimesitylphosphino) -ethyl)ferrocene (7). The frustrated pair [7/8] consumes dihydrogen under similar conditions to yield the reduction products ethylferrocene (14) and Mes2PH · B(C6F5)3 (11).

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 31886-57-4. Computed Properties of C14H19FeN

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Related Products of 492-08-0Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, authors is , once mentioned the new application about Related Products of 492-08-0.

This invention describes the new 8beta-substituted estratrienes of general formula I in which R2, R3, R6, R 6′, R7, R7′, R9, R11, R 11′, R12, R14, R15, R15′, R 16, R16′, R17 and R17′ have the meanings that are indicated in the description, and R8 means a straight-chain or branched-chain, optionally partially or completely halogenated alkyl or alkenyl radical with up to 5 carbon atoms, an ethinyl-or prop-1-inyl radical, as pharmaceutical active ingredients that have in vitro a higher affinity to estrogen receptor preparations of rat prostates than to estrogen receptor preparations of rat uteri and in vivo preferably a preferential action on bone rather than the uterus and/or a pronounced action with respect to stimulation of the expression of 5HT2a-receptors and 5HT2a-transporters, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The invention also describes the use of these compounds for treatment of estrogen-deficiency-induced diseases and conditions as well as the use of an 8beta-substituted estratriene structural part in the total structures of compounds that have a dissociation in favor of their estrogenic action on bones rather than the uterus.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 492-08-0. Related Products of 492-08-0

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of 31886-57-4, Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 31886-57-4, Name is (S)-N,N-Dimethyl-1-ferrocenylethylamine, molecular formula is C14H19FeN. In a article，once mentioned of 31886-57-4

A new method for the determination of enantiomeric composition of N,N-dimetriyl-alpha-ferrocenylethylamine by 1H NMR spectroscopy using (S)-mandelic acid as a chiral protonating agent was proposed.

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Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Career opportunities within science and technology are seeing unprecedented growth across the world, name: (S)-N,N-Dimethyl-1-ferrocenylethylamine, and those who study chemistry or another natural science at university now have increasingly better career prospects. In an article，Which mentioned a new discovery about 31886-57-4

Simple methods have been developed for the preparation of a series of n-alkylferrocenes H(CH2)Fc (n = 3, 5-8, or 12) based on Friedel-Crafts acylation of ferrocenes followed by reduction of the corresponding ketones with Zn amalgam. The properties of H(CH2>nFc and the corresponding ferrocenium ions in micellar aqueous solutions and the behavior of watersoluble cations H(CH2)nFc+ in the absence of micelles were studied by cyclic voltammetry. In all cases, the formal redox potentials of ferrocenes (£ ‘) increase linearly as n increases up to 8. Whether micelles are present or not, the corresponding correlation equation has the following form: £”‘= a + pn, where beta= 29 mV in all cases. The synthesis of (±)-l-ethyI-2methylferrocene from racemic a-dimethylaminoethylferrocene is reported.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 31886-57-4 is helpful to your research. name: (S)-N,N-Dimethyl-1-ferrocenylethylamine

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Having gained chemical understanding at molecular level, Synthetic Route of 31886-57-4, Name is (S)-N,N-Dimethyl-1-ferrocenylethylamine, belongs to chiral-nitrogen-ligands compound, is a common compound. Synthetic Route of 31886-57-4 chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. In an article, authors is , once mentioned the new application about Synthetic Route of 31886-57-4.

The invention relates to a process for the synthesis of aryl hydrazinesof formula I or a salt thereof, which process comprises subjecting an arene of formula II to a coupling reaction with hydrazine or a derivative thereof, wherein the coupling reaction is conducted in the presence of a catalyst comprising palladium and a diphosphine ligand, wherein the phosphorus atoms are connected through two, three, four, or five atoms selected from car- bon, nitrogen, oxygen or iron, and in which the non-connecting phosphorus substituents are C1- C 10-alkyl or C3-C10-cycloalkyl, wherein the amount of Pd used is up to 0.5 mol-% relative to the amount of arene of formula II; and a base.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 31886-57-4 is helpful to your research. Synthetic Route of 31886-57-4

Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

492-08-0, Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 492-08-0, Name is (+)-Sparteine, molecular formula is C15H26N2. In a article，once mentioned of 492-08-0

Drug-induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug effect can occur in various tissues and is suspected to impact cellular viability. Therefore, it is important to test chemical compounds for their potential to induce PLD during the drug design process. PLD has been reported to be a side effect of many commonly used drugs, especially those with cationic amphiphilic properties. To predict drug-induced PLD in silico, we established a high-throughput cell-culture-based method to quantitatively determine the induction of PLD by chemical compounds. Using this assay, we tested 297 drug-like compounds at two different concentrations (2.5muM and 5.0muM). We were able to identify 28 previously unknown PLD-inducing agents. Furthermore, our experimental results enabled the development of a binary classification model to predict PLD-inducing agents based on their molecular properties. This random forest prediction system yields a bootstrapped validated accuracy of 86%. PLD-inducing agents overlap with those that target similar biological processes; a high degree of concordance with PLD-inducing agents was identified for cationic amphiphilic compounds, small molecules that inhibit acid sphingomyelinase, compounds that cross the blood-brain barrier, and compounds that violate Lipinski’s rule of five. Furthermore, we were able to show that PLD-inducing compounds applied in combination additively induce PLD.

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Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis