Tag: M.W=100-200

COA of Formula: C8H7N3O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Exploration of a New Type of Antimalarial Compounds Based on Febrifugine. Author is Kikuchi, Haruhisa; Yamamoto, Keisuke; Horoiwa, Seiko; Hirai, Shingo; Kasahara, Ryota; Hariguchi, Norimitsu; Matsumoto, Makoto; Oshima, Yoshiteru.

Febrifugine (I), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. The use of I as an antimalarial drug has been precluded because of side effects, such as diarrhea, vomiting, and liver toxicity. However, the potent antimalarial activity of I has stimulated medicinal chemists to pursue compounds derived from I, which may be valuable leads for novel drugs. In this study, we synthesized a new series of febrifugine derivatives formed by structural modifications at (i) the quinazoline ring, (ii) the linker, or (iii) the piperidine ring. Then, we evaluated their antimalarial activities. Thienopyrimidine analog II exhibited a potent antimalarial activity and a high therapeutic selectivity both in vitro and in vivo, suggesting that II is a good antimalarial candidate.

There is still a lot of research devoted to this compound(SMILES：O=C1NC(N)=NC2=C1C=CC=C2)COA of Formula: C8H7N3O, and with the development of science, more effects of this compound(20198-19-0) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Patil, Dipak R.; Wagh, Yogesh B.; Ingole, Pravin G.; Singh, Kripal; Dalal, Dipak S. researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole.They published the article 《β-Cyclodextrin-mediated highly efficient [2+3] cycloaddition reactions for the synthesis of 5-substituted 1H-tetrazoles》 about this compound( cas:14389-12-9 ) in New Journal of Chemistry. Keywords: nitrile sodium azide cycloaddition cyclodextrin catalyst; tetrazole preparation environmentally benign chem. We’ll tell you more about this compound (cas:14389-12-9).

A β-cyclodextrin-promoted [2+3] cycloaddition reaction between nitriles and NaN3 in the presence of NH4Cl in DMF at 120 °C was reported, affording various 5-substituted 1H-tetrazoles in good to excellent yields in short reaction times. The presence of β-cyclodextrin renders the formation of a precipitate-like gel in the reaction media when heated. No precipitation occurs in the absence of NaN3 and NH4Cl. The precipitation responses with other salts such as LiCl and NiCl2 were weaker than with NH4Cl. In the present paper the application of supramol. aggregates was reported for the [2+3] cycloaddition reaction. β-cyclodextrin could be recovered and reused without any significant loss of activity.

From this literature《β-Cyclodextrin-mediated highly efficient [2+3] cycloaddition reactions for the synthesis of 5-substituted 1H-tetrazoles》,we know some information about this compound(14389-12-9)Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole, but this is not all information, there are many literatures related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Synthesis and reactivity of a new Fe(II) 5-(4-pyridyl)-tetrazolate complex and X-ray structure of its doubly protonated derivative..

The synthesis of the new Fe(II) complex [CpFe(CO)2(N4C-C5H4N)] (2) is described. Proton and 13C-NMR spectroscopy data of (2) indicate interannular conjugation in the pyridyl-tetrazolate ligand, implying coplanarity between the two rings. Addition of electrophiles to 2 gave cationic complexes such as [CpFe(CO)2(4-MeN4C-C5H4N)][O3SCF3] (3), [CpFe(CO)2(4-HN4C-C5H4N)][O3SCF3] (4) and the doubly protonated complex [CpFe(CO)2(4-HN4C-C5H4N-H)][O3SCF3]2 (5). For example 2 reacted with CH3OSO2CF3 in CH2Cl2 at -50 °C to give 3 in 70% yield. In all cases, the out-of-plane rotation of the pyridyl ring occurred as a consequence of the quaternization of the N-4 of tetrazole ring. X-ray structure of complex 5 indicates a torsion angle of 20.9(2)° between the aromatic rings (space group = P21/n ; a = 15.3345(7), b = 8.3672(4), c = 18.725(1) ; Z = 4). Protonation reactions are reversible and complexes 4-5 were easily converted into the starting complex 2 by addition of a base.

From this literature《Synthesis and reactivity of a new Fe(II) 5-(4-pyridyl)-tetrazolate complex and X-ray structure of its doubly protonated derivative.》,we know some information about this compound(14389-12-9)Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole, but this is not all information, there are many literatures related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zanarini, Simone; Bard, Allen J.; Marcaccio, Massimo; Palazzi, Antonio; Paolucci, Francesco; Stagni, Stefano researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).Safety of 5-(4-Pyridyl)-1H-tetrazole.They published the article 《Ruthenium(II) Complexes Containing Tetrazolate Group: Electrochemiluminescence in Solution and Solid State》 about this compound( cas:14389-12-9 ) in Journal of Physical Chemistry B. Keywords: ruthenium bipyridine terpyridine tetrazolate electrochemiluminescence phosphorescence. We’ll tell you more about this compound (cas:14389-12-9).

The authors report the results about the solution and solid-state phosphorescence emission properties of six RuII complexes containing various 5-substituted tetrazolate ligands. The photo- and electrochemiluminescence spectra of all compounds revealed a red shifted emission with respect to the Ru(bpy)32+. Significant changes to the light emission energy and to the efficiency and sensitivity to oxygen were also determined by varying the nature of the substituent ring of the tetrazolate ligand. Light-emitting solid devices with active layers containing solid films of the same complexes were prepared, and preliminary studies of their electroinduced emission properties were performed. The electrochemiluminescence (ECL) emission intensity of two of the six complexes was of the same order of magnitude as the reference Ru(bpy)32+.

From this literature《Ruthenium(II) Complexes Containing Tetrazolate Group: Electrochemiluminescence in Solution and Solid State》,we know some information about this compound(14389-12-9)Safety of 5-(4-Pyridyl)-1H-tetrazole, but this is not all information, there are many literatures related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C6H5N5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about A Rare 3D Porous Inorganic-Organic Hybrid Polyoxometalate Framework Based on a Cubic Polyoxoniobate-Cupric-Complex Cage with a High Water Vapor Adsorption Capacity. Author is Zhu, Zeng-Kui; Lin, Ya-Yun; Lin, Li-Dan; Li, Xin-Xiong; Sun, Yan-Qiong; Zheng, Shou-Tian.

A rare 3D porous inorganic-organic polyoxoniobate framework based on the cubic polyoxoniobate-cupric-complex cage {[Cu(en)2]@{[Cu2(en)2(trz)2]6(Nb68O188)}} (1a), was successfully synthesized by a hydrothermal method. The cubic cages 1a are connected with 4-(tetrazol-5-yl)pyridine to form a 1D pillar-like chain structure, and every 1D pillar-like chain is further linked with four adjacent pillar-like chains by the [Cu(en)2]2+ complex to form a 3D porous inorganic-organic polyoxoniobate framework with 4-connected CdSO4-type topol. To our knowledge, it is the first time that three different types of organic ligands are simultaneously introduced into one polyoxoniobate. This material also exhibits a high vapor adsorption capacity and good ionic conductivity properties. A novel 3D porous inorganic-organic hybrid polyoxometalate framework, H20Cu(en)[Cu(en)2]11{[1a][4-Tzp]}2·22en·130H2O (1; en = ethylenediamine; Htrz = 1,2,4-triazole; 4-Tzp = 4-(tetrazol-5-yl)pyridine, 1a = {[Cu(en)2]@{[Cu2(en)2(trz)2]6(Nb68O188)}}22-), based on the cubic polyoxoniobate-cupric-complex cage 1a was successfully synthesized. The cubic cages 1a are connected by 4-Tzp and a [Cu(en)2]2+ complex to form a 3D framework with 4-connected CdSO4-type topol. Compound 1 contains three different ligands and exhibits a high vapor adsorption capacity and a good ionic conductivity

From this literature《A Rare 3D Porous Inorganic-Organic Hybrid Polyoxometalate Framework Based on a Cubic Polyoxoniobate-Cupric-Complex Cage with a High Water Vapor Adsorption Capacity》,we know some information about this compound(14389-12-9)Computed Properties of C6H5N5, but this is not all information, there are many literatures related to this compound(14389-12-9).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 5-(4-Pyridyl)-1H-tetrazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Synthesis, photophysical and electrochemical investigation of dinuclear tetrazolato-bridged rhenium complexes.

Rhenium binuclear tetrazolylbenzonitrile and tetrazolylpyridine-bridged phenanthroline complexes exhibit emission at 490-560 nm in CH2Cl2 solution both at room temperature and at 77 K. Starting from anionic tetrazole-based ligands, namely, 5-(4′-cyanophenyl)tetrazolate and 5-(4′-pyridyl)tetrazolate, mononuclear and dinuclear complexes of fac-[Re(CO)3(phen)]+ (phen = 1,10-phenanthroline) were prepared and characterized. For the mononuclear complexes, regioselective coordination of the metal fragments on the neg. charged tetrazolato ring is exclusively obtained. Coordination to the benzonitrile and pyridine groups was achieved by previous alkylation of the tetrazole ring. Dinuclear complexes were obtained by treatment of the corresponding mononuclear tetrazole-bound complexes with fac-[Re(CO)3(phen)(THF)]+. The second rhenium fragment coordinated either to the pyridine ring or, in the case of the benzonitrile ligand, to the tetrazole ring. The electrochem. properties were probed in an imidazolium ionic liquid, highlighting reduction processes centered on the phen ligand and oxidation processes localized on the metal. The photophys. properties of the complexes are characterized by phosphorescent emission from triplet metal-to-ligand charge transfer excited states, with trends in the lifetime and quantum yield in qual. agreement with the energy gap law. The two dinuclear complexes show almost superimposable emission profiles: in the 5-(4′-cyanophenyl)tetrazolate-bridged complex, the two metal fragments coordinated to the tetrazole are equivalent and share a pos. charge of +1. On the other hand, the photophys. properties of the 5-(4′-pyridyl)tetrazolate-bridged dinuclear complex suggest energy transfer between the two metal centers.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Optimizing Fragment and Scaffold Docking by Use of Molecular Interaction Fingerprints, the main research direction is protein ligand scaffold docking mol interaction fingerprint.Product Details of 20198-19-0.

Protein-ligand interaction fingerprints have been used to postprocess docking poses of three ligand data sets: a set of 40 low-mol.-weight compounds from the Protein Data Bank, a collection of 40 scaffolds from pharmaceutically relevant protein ligands, and a database of 19 scaffolds extracted from true cdk2 inhibitors seeded in 2230 scaffold decoys. Four popular docking tools (FlexX, Glide, Gold, and Surflex) were used to generate poses for ligands of the three data sets. In all cases, scoring by the similarity of interaction fingerprints to a given reference was statistically superior to conventional scoring functions in posing low-mol.-weight fragments, predicting protein-bound scaffold coordinates according to the known binding mode of related ligands, and screening a scaffold library to enrich a hit list in true cdk2-targeted scaffolds.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

COA of Formula: C8H7N3O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Heterocyclic photorearrangements. Some investigations of the photochemical behavior of 3-acylamino-1,2,4-oxadiazoles. Synthesis of the quinazolin-4-one system. Author is Buscemi, Silvestre; Vivona, Nicolo.

Some mechanistic investigations on the photochem. behavior of 1,2,4-oxadiazoles are reported. Irradiation of 3-benzoylamino-5-methyl-1,2,4-oxadiazole at λ = 254 nm in methanol involves excitation of the benzoylamino group chromophore to a triplet state species and induces a 6π electrocyclic closure to a tricyclic intermediate. On the other hand, irradiation of 3-acetylamino-5-phenyl-1,2,4-oxadiazole at λ =254 nm involves excitation of a 5-phenyl-substituted oxadiazole chromophore which leads to the photolysis of the ring O-N bond in a singlet state species. Furthermore, irradiation of some selected 5-Ph substituted oxadiazoles in the presence of a triplet sensitizer produces an excited triplet state species which collapses in a ring closure reaction involving the C5-Ph moiety.

Here is a brief introduction to this compound(20198-19-0)COA of Formula: C8H7N3O, if you want to know about other compounds related to this compound(20198-19-0), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name: 2-Aminoquinazolin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Derivatives of 4-quinazolone as heat stabilizers for poly(vinyl chloride) and vinyl chloride-vinyl acetate copolymers. Author is Kasymova, S. S.; Masharipov, S. M.; Tadzhieva, Kh. S.; Makhmudov, S. A.; Yun, L. M.; Shakhidoyatov, Kh. M..

The stabilizing effect of 4-quinazolone  [491-36-1], 2-amino-4-quinazolone (I) [20198-19-0], 2-amino-3-methyl-4-quinazolone (II) [91810-61-6] and 2-amino-3-methyl-6-nitro-4-quinazolone  [91810-62-7] on PVC  [9002-86-2] and vinyl acetate-vinyl chloride copolymer  [9003-22-9] was studied. The highest heat resistance of the polymers was obtained by stabilization with I, and to a lower degree, with II, whereas the other quinazolone derivatives had no stabilizing effect on the polymers. The effect of mixtures of II with com. stabilizers Ca stearate or Ba-Cd stearate on the heat resistance of PVC depended nonmonotonically on the component ratio, whereas the effect of mixtures of I and other quinazolone derivatives with com. stabilizers increased with increasing content of the former.

If you want to learn more about this compound(2-Aminoquinazolin-4(3H)-one)Name: 2-Aminoquinazolin-4(3H)-one, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(20198-19-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: 20198-19-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about 2-Aminoquinazolin-4(3H)-one as an Organocatalyst for the Synthesis of Tertiary Amines. Author is Thakur, Maheshwar S.; Nayal, Onkar S.; Upadhyay, Rahul; Kumar, Neeraj; Maurya, Sushil K..

The potential of 2-aminoquinazolin-4(3H)-one as an organocatalyst for the activation of aldehydes via noncovalent interaction for the synthesis of tertiary amines using formic acid as a reducing agent is reported for the first time. The developed protocol demonstrated a dilated substrate scope for aromatic and aliphatic amines with aromatic and aliphatic aldehydes. Furthermore, the current method was also fruitful for the derivatization of ciprofloxacin and its derivative in good to excellent yields.

If you want to learn more about this compound(2-Aminoquinazolin-4(3H)-one)HPLC of Formula: 20198-19-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(20198-19-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis