Tag: M.W=100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-(4-Pyridyl)-1H-tetrazole(SMILESS: C1(C2=NN=NN2)=CC=NC=C1,cas:14389-12-9) is researched.Safety of 2-(7-Bromo-1H-indol-3-yl)acetic acid. The article 《Secondary spacer modulated assembly of polyoxometalate based metal-organic frameworks》 in relation to this compound, is published in Dalton Transactions. Let’s take a look at the latest research on this compound (cas:14389-12-9).

To study the influence of a secondary spacer on the resulting structures of POMOFs containing pytz, five new compounds with different dimensionalities, [Cu5(2-pytz)6(H2O)4][SiMo12O40]·3H2O (1), [Cu3(2-pytz)4bipy][H2SiMo12O40]·bipy (2), [Cu3(2-pytz)2(bipy)4(H2O)6][H4SiW12O40]2·6H2O (3), [Cu2(2-pytz)(phen)(OH)]2[SiW12O40]·H2O (4), [Cu3(4-pytz)4(H2O)4][H2SiW12O40]·2H2O (5) (pytz = pyridyltetrazole), were synthesized. When only 2-pytz was employed, compound 1 with a 3D framework was obtained, whereas when the secondary spacers (4,4′-bipy, phen and 4-pytz) were introduced into the reaction system of 1, compounds 2-5 were obtained and exhibit a broad range of structures, including 0D, 1D, 2D and 3D frameworks. It can be observed from the architectures of compounds 1-5 that the secondary spacers have a great effect on the structures of the MOFs, which gave various dimensional POMOF compounds Addnl., photocatalytic experiments of 1-5 for the photocatalytic degradation of RhB under UV irradiation were also studied.

This literature about this compound(14389-12-9)Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazolehas given us a lot of inspiration, and I hope that the research on this compound(5-(4-Pyridyl)-1H-tetrazole) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Fernandes, Daniel J.; Cardenas, Rafael M.; Bertino, Joseph R.; Hynes, John B. published an article about the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2 ).Formula: C8H7N3O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20198-19-0) through the article.

A series of title compounds (I; Z = NHCH2, CH2NH, CH2NMe, CH2S, CH2O, (CH2)2, CHONCH2) were evaluated as inhibitors of colon adenocarcinoma and the folate-dependent enzymes, thymidylate synthase  [9031-61-2] and dihydrofolate reductase  [9002-03-3]. Of the drugs tested, IAHQ (I; Z = NHCH2) [56239-21-5], when administered at 85 mg/kg on days 2 and 10 after tumor implantation, delayed the growth of colon tumor Number 38, and resulted in 6 of 20 tumor-free animals at 90 days. In contrast, methotrexate had no effect on the growth of colon tumor Number 38 at maximally tolerated doses. IAHQ was also active against human colon adenocarcinoma cells (HCT-8) in tissue culture, requiring a concentration of 5 × 10-7 M to inhibit cell growth by 50% after 72 h continuous exposure.

This literature about this compound(20198-19-0)Formula: C8H7N3Ohas given us a lot of inspiration, and I hope that the research on this compound(2-Aminoquinazolin-4(3H)-one) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Preparation and aminolysis of 4-hydroxyquinazoline-2-sulfonic acid, published in 1965, which mentions a compound: 20198-19-0, mainly applied to , Category: chiral-nitrogen-ligands.

A saturated solution of KMnO4 is added to a solution of 8.9 g. 2-mercapto-4-hydroxyquinazoline (I) and 28 g. KOH in 100 ml. H2O at 45°, the mixture filtered, and the filtrate cooled to 0°. AcOH is added to a pH 6.5, the whole cooled to -5°, and the precipitate filtered off, and recrystallized from 70% EtOH at 0° to give a 60% yield of K 4-hydroxyquinazoline-2-sulfonate (II) (no m.p.). II is adjusted with HCl to pH 4 and heated to 100° to yield 2,4-dihydroxyquinazoline, m. 348-50°. II (2.64 g.) in 6 ml. of 2M aqueous Me2NH heated 4 hrs. at 130° gives 1.74 g. of 2-dimethylamino-4-hydroxyquinazoline (III), m. 244-6°. III.HCl m. 275°. The following analogs (IV) of III were prepared (R, % yield, m.p., and m.p. Ac derivative given): H, 90.6, 315-16°, 278-80°; Me, 74.2, 275-6°, 194-6°; Et, 82.9, 231-2°, 120-2°; Pr, 84.5, 199-200°, 118-19°; Bu, 88.4, 187-8°, 110-12°; Ph, 89.7, 260-3°, 203-4°; CH2Ph, 92.2, 214-15°, 124-5°; C6H4OMe-p, 85.7, 271-2°, 204-5°; C6H4Me-p, 91.2, 268-70°, 206-9°; cyclohexyl, 32.0, 209-11°, 204-5°; CH2CH2OH, 96.0,249-50°, -; 1-pyrrolidyl 73.2, 223-4°, -.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Tripuramallu, Bharat Kumar; Manna, Paulami; Das, Samar K. published an article about the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9,SMILESS:C1(C2=NN=NN2)=CC=NC=C1 ).SDS of cas: 14389-12-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:14389-12-9) through the article.

Herein we report 6 new coordination polymers [Co(1,2-pda)(1,2-bix)]n, [Co(hfipbb)(1,2-bix)]n.nH2O, [Co(ADA)(1,2-bix)]n, [Co(ADA)(1,3-bix)]n.nH2O, [Co(1,4-pda)2(2-pztz)]2[Co(H2O)6].2nH2O, [Co2(μ-OH)(1,3-pda)(4-ptz)]n based on the flexible carboxylate ligands 1,2-phenylenediacetic acid (1,2-H2pda), 1,3-phenylenediacetic acid (1,3-H2pda), 1,3-adamantanediacetic acid (H2ADA), 4,4′-(hexafluoroisopropylidene)bis(benzoic acid) (H2hfipbb) and secondary N-donor ligands 1,3-bis(imidazole-1-ylmethyl)-benzene (1,3-bix), 1,2-bis(imidazole-1-ylmethyl)-benzene (1,2-bix), 5-(4-pyridyl)tetrazole (4-ptz), and 2-(2H-tetrazol-5-yl)pyrazine (2-pztz). All the compounds were characterized by single crystal x-ray diffraction anal., IR spectroscopy, elemental anal. and bulk homogeneity by powder x-ray diffraction. A subtle relation between the position of the coordinating groups in the linker (known as linker coordination angle, LCA) and the dimensionality and topol. of the final architectures of the title compounds was discussed systematically by comparing with the structurally related reported compounds [Co(1,4-pda)(1,4-bix)]n, [Co(hfipbb)(1,4-bix)0.5]n, and [Co2 (μ-OH)(1,4-pda)(4-ptz) ]n.nH2O. The compounds studied are classified into four different mixed linker classes, based on the skeleton geometry of the linker. Finally, temperature dependent magnetic susceptibility measurements were studied and the relevant zero-field splitting parameters were determined

As far as I know, this compound(14389-12-9)SDS of cas: 14389-12-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Article, Inorganic Chemistry called A Highly Connected Trinuclear Cluster Based Metal-Organic Framework for Efficient Separation of C2H2/C2H4 and C2H2/CO2, Author is Li, Qian; Wu, Nana; Li, Jia; Wu, Dapeng, the main research direction is cobalt MOF preparation acetylene adsorption separation ethylene carbon dioxide; crystal structure cobalt dihydroxybenzenedicarboxylate pyridyltetrazolate MOF trinuclear cluster.Formula: C6H5N5.

One of the barriers for efficient gas separation is the trade-off between the selectivity and adsorption capacity. To address this issue, the authors synthesized an anionic trinuclear CoII based 3-dimensional MOF (NH4)[Co3(OH)(4-Ptz)3(DOBDC)1.5]·3EtOH·2.5H2O (NbU-8, DOBDC = 2,5-dioxido-1,4-benzenedicarboxylate, HPtz = 5-(4-pyridyl)tetrazolate), which was characterized by an ultramicroporous building unit (UBU) and Lewis basic binding sites on the pore surfaces. Remarkably, the combination of the two strategies can synergistically enhance the C2H2 adsorption capacity (182.9 cm3/g at 298 K) and simultaneously achieve a high separation performance toward C2H2/C2H4 and C2H2/CO2 mixtures Besides theor. calculations, the separation efficiencies of C2H2/C2H4 and C2H2/CO2 are also demonstrated using breakthrough experiments D. functional theory calculations further confirmed the -OH groups and ultramicroporous building units play an important synergistic effect in efficiently capturing acetylene mols. Through a synergy strategy, a highly connected trinuclear CoII based metal-organic framework (NbU-8) was synthesized. It shows an excellent separation performance toward C2H2/C2H4 and C2H2/CO2, which is proved by breakthrough experiments and d. functional theory calculations

As far as I know, this compound(14389-12-9)Formula: C6H5N5 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 2-Aminoquinazolin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation. Author is Loving, Kathryn; Salam, Noeris K.; Sherman, Woody.

We have developed a method that uses energetic anal. of structure-based fragment docking to elucidate key features for mol. recognition. This hybrid ligand- and structure-based methodol. uses an at. breakdown of the energy terms from the Glide XP scoring function to locate key pharmacophoric features from the docked fragments. First, we show that Glide accurately docks fragments, producing a root mean squared deviation (RMSD) of <1.0 Å for the top scoring pose to the native crystal structure. We then describe fragment-specific docking settings developed to generate poses that explore every pocket of a binding site while maintaining the docking accuracy of the top scoring pose. Next, we describe how the energy terms from the Glide XP scoring function are mapped onto pharmacophore sites from the docked fragments in order to rank their importance for binding. Using this energetic anal. we show that the most energetically favorable pharmacophore sites are consistent with features from known tight binding compounds Finally, we describe a method to use the energetically selected sites from fragment docking to develop a pharmacophore hypothesis that can be used in virtual database screening to retrieve diverse compounds We find that this method produces viable hypotheses that are consistent with known active compounds In addition to retrieving diverse compounds that are not biased by the co-crystallized ligand, the method is able to recover known active compounds from a database screen, with an average enrichment of 8.1 in the top 1% of the database. As far as I know, this compound(20198-19-0)Safety of 2-Aminoquinazolin-4(3H)-one can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

SDS of cas: 14389-12-9. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Group II metal-directed structural variation of coordination compounds derived from 5-[N-acetato(4-pyridyl)]tetrazolate ligand.

Reactions of MCl2 (M = Mg, Ca, Sr, Ba) and a4-ptz (a4-ptz = 5-[N-carboxymethyl(4-pyridyl)]tetrazolate) potassium salt in water, resp., and produced four complexes, [Mg(H2O)6]·(a4-ptz)2·2H2O (1), [Ca(a4-ptz)2(H2O)4]n·2nH2O (2), [Sr(a4-ptz)2(H2O)4]n·2nH2O (3), [Ba4(a4-ptz)8(H2O)16]n·4nH2O (4). These compounds were structurally characterized by elemental anal., IR spectroscopy and single-crystal x-ray diffraction. Compound 1 has a mononuclear structure bearing distinct intermol. hydrogen-bond interactions to form a three-dimensional supramol. network. Compounds 2-4 have 1-dimensional polymeric chains that are bridged by two water mol. linkers. The luminescence properties of 1-4 were studied at room temperature in the solid state.

As far as I know, this compound(14389-12-9)SDS of cas: 14389-12-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

COA of Formula: C6H5N5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about A rapid and green synthetic approach for hierarchically assembled porous ZnO nanoflakes with enhanced catalytic activity. Author is Sinhamahapatra, Apurba; Giri, Arnab Kanti; Pal, Provas; Pahari, Sandip Kumar; Bajaj, Hari C.; Panda, Asit Baran.

Three dimensionally (3D) assembled hierarchical porous ZnO structures are of key importance for their applications in sensors, lithium-ion batteries, solar cells and in catalysis. Here, the controlled synthesis of 3D hierarchically porous ZnO architectures constructed of two dimensional (2D) nano-sheets through the calcination of a hydrozincite [Zn5(CO3)2(OH)6] intermediate is presented. The intermediate 3D hierarchical hydrozincite has been synthesized by a novel organic surfactant and solvent free aqueous protocol at room temperature using an aqueous solution of ammonium carbonate and laboratory grade bulk ZnO in a short time (20-30 min). The amount of carbonate and the reaction temperature play a crucial role in the formation of the 3D hierarchical morphol. and on the basis of the exptl. results a probable reaction mechanism is proposed. On calcination, the synthesized 3D hierarchical hydrozincite resulted in ZnO with an almost identical morphol. to the parental hydrozincite. On decomposition a porous structure having a surface area of 44 M2 g-1 is obtained. The synthesized hierarchical ZnO morphol. exhibits an improved catalytic activity for the synthesis of 5-substituted-1H-tetrazoles with different nitriles and sodium azide than that of nanocrystalline ZnO and bulk ZnO, as well as other developed solid catalysts. The catalyst is easily recyclable without a significant loss in catalytic activity.

There is still a lot of research devoted to this compound(SMILES：C1(C2=NN=NN2)=CC=NC=C1)COA of Formula: C6H5N5, and with the development of science, more effects of this compound(14389-12-9) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name: 2-Aminoquinazolin-4(3H)-one. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Dicopper complexes catalyzed coupling/cyclization of 2-bromobenzoic acids with amidines leading to quinazolinones. Author is Hung, Ming-Uei; Liao, Bei-Sih; Liu, Yi-Hong; Peng, Shie-Ming; Liu, Shiuh-Tzung.

Dicopper(I) complexes {[Cu2(bpnp)(MeCN)4](PF6)2} (I), {[Cu2(bpnp)(MeCN)4](BAr4F)2} {BAr4F = B[C6H3-3,5-(CF3)2]4}, and [Cu2(bpnp)Cl2] (II) were prepared from the complexation of [Cu(MeCN)4](PF6) with 2,7-bis(2-pyridyl)-1,8-naphthyridine (bpnp) followed by anion metathesis and treatment of chloride sequentially. X-ray structural anal. of II (data deposited with the CCDC) indicates the mol. to have a 2-fold axis passing through the Cu2Cl2 core, which has the shape of a butterfly, and that the Cu atom is tetrahedrally coordinated with in a Cl2N2 donor set. In preliminary experiments, I was found to be an effective catalyst in the coupling/cyclization of 2-bromobenzoic acids with amidines, providing the corresponding quinazolinones in good yields. Copyright © 2014 John Wiley & Sons, Ltd.

There is still a lot of research devoted to this compound(SMILES：O=C1NC(N)=NC2=C1C=CC=C2)Name: 2-Aminoquinazolin-4(3H)-one, and with the development of science, more effects of this compound(20198-19-0) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Name: 5-(4-Pyridyl)-1H-tetrazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about In-situ hydrothermal preparation of a novel 3D CuI-based tetrazole coordination polymer with pseudo-porphyrin secondary building units. Author is Dong, Dapeng; Yu, Naisen; Cong, Yan; Zhao, Ying; Zhao, Haiyan; Liu, Dedi; Li, Zhenghua; Liu, Jia; Liu, Dongping.

A novel 3-dimensional CuI-based tetrazole coordination polymer through the employment of in-situ solvothermal techniques by using 4-cyanopyridine, NaN3 and CuI, [Cu5(L)3I2] (1) (HL = 5-(4-pyridyl)-1H-tetrazole) was synthesized and structurally characterized by x-ray single-crystal diffraction as well as by powder X-ray diffraction, elemental anal. and TGA. In compound 1, each CuN3I tetrahedron, CuN2I2 tetrahedron and CuN3 triangle are linked to each other by L ligand to form a 3-dimensional framework structure. It is interesting to note that the interconnection of Cu1 and Cu2 ions by bridging L ligand form pseudo-porphyrin secondary building units. Surface photovoltage, field-induced surface photovoltage and luminescent properties of compound 1 also were studied.

There is still a lot of research devoted to this compound(SMILES：C1(C2=NN=NN2)=CC=NC=C1)Name: 5-(4-Pyridyl)-1H-tetrazole, and with the development of science, more effects of this compound(14389-12-9) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis