Tag: M.W=100-200

Category: chiral-nitrogen-ligands. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about 2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.

A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochem. of the amino alc. was found to influence the TLR7/8 selectivity with the (R) isomer resulting in selective TLR8 agonism. Lead optimization toward a dual agonist afforded (S)-3-((2-amino-8-fluoroquinazolin-4-yl)amino)hexanol 31 as a potent analog, being structurally different from previously described dual agonists (McGowan J. Med. Chem. 2016, 59, 7936). Pharmacokinetic and pharmacodynamic (PK/PD) studies revealed the desired high first pass profile aimed at limiting systemic cytokine activation. In vivo pharmacodynamic studies with lead compound 31 demonstrated production of cytokines consistent with TLR7/8 activation in mice and cynomolgus monkeys and ex vivo inhibition of hepatitis B virus (HBV).

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganica Chimica Acta called Three-dimensional bimetallic oxides constructed from molybdophosphonate chains and secondary-metal/4-pyridyltetrazole components, Author is Jones, Stephanie; Darling, Kari; Zubieta, Jon, which mentions a compound: 14389-12-9, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5, Quality Control of 5-(4-Pyridyl)-1H-tetrazole.

The hydrothermal reactions of molybdenum(VI) oxide, 1,2-ethylenediphosphonic acid, 4-pyridyltetrazole (4-Hpt) and the appropriate metal acetate yielded three-dimensional bimetallic oxides [Mx(4-Hpt)y(H2O)z{Mo5O15(O3PCH2CH2PO3)}]·nhydrate (M = Co or Ni, x = 2, y = 2, z = 6; M = Cu, x = 4, y = 3, z = 1). The Co(II) and Ni(II) phases are isomorphous with structures constructed from the common {Mo5O15(O3PCH2CH2PO3)}n4n- chains linked through binuclear {M2(4-Hpt)2(H2O)6}4+ subunits to provide the three-dimensional connectivity. The Cu(I) species consists of the molybdophosphonate chains embedded in a framework of Cu(I) tetrahedra linked through the tetrazole N donors of the 4-Hpt ligands.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zeitschrift fuer Anorganische und Allgemeine Chemie called Direct Synthesis and Characterization of New Copper(II) and Zinc(II) 5-R-Tetrazolato Complexes [R = Me, Ph, 4-Py] with Ethylenediamine and DMSO as Coligands, Author is Mosalkova, Anastasiya P.; Voitekhovich, Sergei V.; Lyakhov, Alexander S.; Ivashkevich, Ludmila S.; Gaponik, Pavel N.; Ivashkevich, Oleg A., which mentions a compound: 14389-12-9, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5, Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole.

Three novel 5-R-tetrazolato complexes (R = Me, Ph, 4-Py), [Zn2(MeCN4)4(DMSO)2]n (1), [Cu2(PhCN4)4(en)2]·2DMSO (2), and {[Cu(4-PyCN4)2(DMSO)2]·4DMSO}n (3), were isolated as unexpected products under attempts to prepare heterometallic tetrazolates using a direct synthesis strategy in the Cu0-ZnO-en-RCN4H-DMSO system (en = ethylenediamine). The prepared compounds were characterized by elemental, single-crystal x-ray, and thermal analyses, and IR spectroscopy. Variation of the 5-substituent of the tetrazole ring causes different composition of complexes 1-3 and diverse coordination modes of 5-R-tetrazolato ligands. Complex 1 is a 3-dimensional coordination polymer due to N1,N4-bridging of 5-methyltetrazolato anions. Complex 2, with en as a coligand, has a dinuclear structure with two copper atoms linked together by two 5-phenyltetrazolato ligands by tetrazole N2,N3 bridges. Complex 3 represents a 2-dimensional coordination polymer, formed due to 5-(4-pyridyl)tetrazolato bridges between adjacent copper atoms (with the tetrazole and pyridine rings nitrogen atoms as coordination centers). DMSO mols., included in all the compounds, are solvate and/or coordinated ones.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ) is researched.Computed Properties of C6H5N5.Song, Wei-Chao; Pan, Qinhe; Song, Peng-Chao; Zhao, Qiang; Zeng, Yong-Fei; Hu, Tong-Liang; Bu, Xian-He published the article 《Two unprecedented 10-connected bct topological metal-organic frameworks constructed from cadmium clusters》 about this compound( cas:14389-12-9 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: unprecedented ten connected bct organic framework cadmium cluster preparation; cadmium isophthalic acid pyridyl tetrazole metal organic framework preparation; crystal mol structure cadmium isophthalic acid pyridyl tetrazole cluster. Let’s learn more about this compound (cas:14389-12-9).

By simply modifying the expansion of ligand tether length, two Cd(ii) metal-organic frameworks have been constructed from linear tetranuclear and trinuclear cadmium clusters, resp., which present an unprecedented 10-connected unimodal bct net.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Cyclic amidines. X. 2-Aminoquinazoline derivatives》. Authors are Grout, R. J.; Partridge, M. W..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Name: 2-Aminoquinazolin-4(3H)-one. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

cf. CA 54, 3439a. 2-(Substituted amino)- and 3-substituted 2-aminoquin-azolines were produced by interaction of a urea, an arenesulfonyl chloride, and Me anthranilate (I). Rearrangements of 3-substituted 2-amino-3,4-dihydro-4-oxoquinazolines to their 2-(substituted amino)isomers, aminolyzes, alkylations, and transalkylations of quinazoline derivatives were examined None of the compounds reported was of therapeutic interest. EtNHCONH2 (8.8 g.) suspended in 30 mL. C5H5N treated during 10 min. at 0° with 17.7 g. PhSO2Cl, the mixture kept overnight at 0°, and heated 4 h. with 15.1 g. I gave 6.1 g. 4-hydroxyquinazolinium chloride, m. 293° (decomposition) (EtOCH2CH2OH). The free base m. 232° (Me2CO); picrate m. 274-5° (decomposition) (AcOH); acetyl derivative, prisms, m. 121-2° (C6H6-ligroine). The C5H5N mother liquor from the isolation of the foregoing chloride evaporated, and the residue codistd. with 130 mL. NH4OH gave 3 g. 4-oxoquinazoline, prisms, m. 186-7° (H2O); picrate, prisms, m. 282-4° (decomposition); acetyl derivative, prisms, m. 158-9° (C6H6-ligroine). The following 4-hydroxy-2-substituted-aminoquinazolines were thus obtained (substituent, m.p., % yield, m.p. of picrate, and m.p. of Ac derivative given): Me, 276°, 7, 294°, 196°; Pr, 198.5-200°, 34 (0.5HCl salt m. 292.5-3.5°) 252°, 118-19°; iso-Pr, 212-13°, 45, 264°, 129-30°; Bu, 187-8°, 39 (0.5HCl salt m. 258-9°), 240°; 111-12°; Me(CH2)4, 157.5-9.0°, 40 (0.5HCl salt m. 235°) 215-16°, 60-2°; cyclohexyl, 209-10°, 58 (0.5HCl salt m. 283°) 267°, 204-5°; PhCH2, 213.5-14.5°, 49, 236°, 124-5°; Ph, 261°, 19, 268°, 202-4° p-C6H4Me, 268-9°, 32, semipicrate, 285°; 209°; o-C6H4Me, 287-9°, 41, 255-6°, 154-6°; p-MeOC6H4, 271-2°, 36, -, 204-5°. The following 2-amino-3,4-dihydro-3-substituted-4-oxoquinazolines were thus obtained [3-substituent, m.p., % yield, m.p. of picrate, and m.p. of Ac derivative given]: Me, 242°, 46, 282-3°, 156-7°; Pr, 186-8°, 16.5, 261°, 151-2°; Bu, 192°, 11, 228-9°, acetyl, 140-1°; Me(CH2)4, 177°, 16, 250°, 96°; PhCH2, 202-4°, 9, 270°, 189-90°; Ph, 252°, 23 (HCl salt m. 291-2°), 268-9°; diacetyl, 209°; p-MeOC6H4, 234-6°, 5 (p-toluenesulfonate m. 258-9°), 271-2°; diacetyl, 206-8°. Pentylamine (17.4 g.) in 20 mL. concentrated HCl and 50 mL. H2O treated with 13 g. NaOCN in 100 mL. H2O gave 17.5 g. pentylurea, b17 137-9°; oxime, m. 102°. Methylphenylcyanamide (3 g.) and 7.4 g. o-methoxycarbonylanilinium p-toluenesulfonate in aqueous alkali heated 2 h. at 210° gave 1.3 g. 4-hydroxy-2-N-methylanilinoquinazoline, prisms, m. 197.5-8.5°; p-toluenesulfonate, prisms, m. 173-4° (alc.-Et2O). p-Methoxyphenylcyanamide (9.8 g.) and 11.4 g. 2-diethylaminoethyl chloride HCl salt refluxed 1 h. in 150 mL. alc. containing 3 g. Na gave 11.3 g. (2-diethylaminoethyl)-p-methoxyphenylcyanamide, m. 31-3°, b4 184°, and 1.4 g. tri-p-methoxyphenylisomelamine, m. 212°. 2-Chloro-4-ethoxyquinazoline (II) and PhNHMe refluxed 1 h. in alc. gave 4-ethoxy-2-N-methylanilinoquinazoline, prisms, m. 87-8° (ligroine); picrate m. 189-90° (decomposition). II (2.3 g.) and 1.2 g. p-anisidine refluxed 1 h. in 20 mL. alc. gave 2.9 g. 2-p-anisidino-4-ethoxyquinazoline, prisms, m. 98-9° (ligroine); picrate m. 179-80° (Me2CO). PhSO2Cl (17.7 g.) added at 0° to 19.4 g. o-ureidobenzoate suspended in 30 mL. C5H5N, and kept overnight at 0° gave 4.9 g. Me o-cyanamidobenzoate, m. 105-6° and 3.5 g. 2,4-dihydroxyquinazoline, m. 349-50°. The alkali insoluble fraction yielded 8.1 g. Me o-benzenesulfonylcyanamidobenzoate, prisms, m. 108° (iso-PrOH). 2-Amino-3,4-dihydro-4-oxo-3-phenylquinazoline (1 g.) refluxed 8 h. with 20 mL. 10N NaOH and the Na salt decomposed with AcOH gave 1 g. 2-anilino-4-hydroxyquinazoline (III), m. 261°; acetyl derivative, m. 202-4°. III was formed in 74% yield when 2-amino-4-hydroxyquinazoline (IIIa) was refluxed 24 h. with 10 mol PhNH2. The following quinazolines were similarly produced by analogous rearrangements and identified by comparison of the base and appropriate derivative with known compounds: 4-hydroxy-2-methylamino-, 95%; 2-ethylamino-4-hydroxy-, 75%; 4-hydroxy-2-propylamino-, 50%; 2-benzylamino-4-hydroxy-, 11%; 4-hydroxy-2-p-methoxyanilino-, 100%, also produced by refluxing 4-ethoxy-2-(p-methoxyanilino-) quinazoline 5 h. with 3N HCl. o-Methoxycarbonylanilinium p-toluenesulfonate (32.3 g.) and 19 g. p-MeC6H4SO3H refluxed 3 h. with 8.4 g. dicyandiamide and 200 mL. H2O gave 15.3 g. p-toluenesulfonate, m. 291-2°. This salt gave 2-guanidino-4-hydroxyquinazoline (IV), m. 310-11° (decomposition). IV (2 g.) refluxed 2 h. with 4 g. KOH in 20 mL. (CH2OH)2, diluted with H2O, and neutralized gave 1.3 g. IIIa, m. 315° (decomposition); picrate m. 258-60° (decomposition); acetyl derivative m. 277-80° (EtOCH2CH2OH). Anthranilic acid (137 g.) in 93 mL. concentrated HCl and 1 l. H2O kept 7 wk with cyanamide gave 86 g. IIIa. IIIa (6.4 g.) and 5.4 g. 2-chloroethyl acetate refluxed 45 min. in 100 mL. alc. containing 0.92 g. Na and 0.6 g. NaI, and left overnight gave 0.8 g. 2-amino-3,4-dihydro-3-(= 2-hydroxyethyl)-4-oxoquinazoline, prisms, m. 224° (alc.); picrate m. 220-1°. CH2ClCH2OH did not effect alkylation. Attempted alkylation of 2-acetamido-4-hydroxyquinazoline with 2-chloroethyl acetate gave only 93% IIIa. 4-Hydroxy-2-methylthioquinazoline (3.8 g.) and 4.6 g. 2-diethylaminoethylamine heated 75 min. at 180° gave 4.1 g. 2-(2-diethylaminoethylamino)-4-hydroxyquinazoline, m. 94-6° (aqueous alc.); picrate m. 234-5° (decomposition); MeI derivative, needles, m. 191-2°; methopicrate, needles, m. 194-5° (H2O). IIIa (3.2 g.) and 12.2 g. ethanolamine refluxed together 6 h. gave 1.15 g. 4-hydroxy-2-(2-hydroxyethylamino)quinazoline, m. 249.5-50.0° (H2O); picrate, needles, m. 212-13° (AcOH). A basic byproduct (1.65 g.), possibly 2,4-bis(2-hydroxyethylamino)quinazoline, crystallized from H2O as prisms, m. 162-3°; picrate m. 226-9° (alc.). Butylamine p-toluenesulfonate prepared in iso-PrOH gave needles, m. 122° (EtOAc). 2-Anilino-4-ethoxyquinazoline (IVa) (2.7 g.) refluxed 1 h. in 30 mL. BuOH containing 0.23 g. Na and poured into H2O gave 2.4 g. 2-anilino-5-butoxyquinazoline (V), prisms, m. 82-3° (alc.); picrate m. 182-3°(alc.). Crude 2-anilino-4-chloroquinazoline (1.1 g.) formed from 2-anilino-4-hydroxyquinazoline and POCl3, furnished 0.2 g. V, when refluxed 16 h. with 25 mL. BuOH containing 0.1 g. Na. IVa (5 g.) afforded 2 g. V, when refluxed 16 h. with 5 g. BuBr in 60 mL. alc. and 0.5 g. Na. The following ethers were obtained by transalkylation similar to that described above: 2-anilino-4-pentyloxyquinazoline (70%), needles, m. 118-19° (iso-PrOH), picrate m. 215-16° (decomposition) and 2-anilino-4-benzyloxyquinazoline (78%), needles, m. 11819° (iso-PrOH), picrate m. 215-16° (decomposition). IVa (5.3 g.) refluxed 1 h. with 60 mL. ethanolamine containing 0.5 g. Na and poured into H2O afforded 5 g. 2-anilino-4-(2-hydroxyethylamino)quinazoline (VI), m. 147-9° (PhMe); picrate, prisms, m. 185° (H2O). At 20°, the reaction yield was 5.15 g. VI was stable to alc. alkali and with HNO2 at 10° gave the nitrite, m. 163-5° (decomposition). 2-Chloro-4-(2-hydroxyethylamino)quinazoline (1 g.) and 0.42 g. PhNH2 in 10 mL. H2O refluxed 45 min. with 0.2 mL. HCl, yielded on basification 1.14 g. VI.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Visible and ultraviolet absorption of some derivatives of 2,4-dioxotetrahydroquinazoline and related open-chain compounds》. Authors are Grammaticakis, Panos.The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Name: 2-Aminoquinazolin-4(3H)-one. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

The visible and ultraviolet light absorption of derivatives of 4-oxotetrahydroquinazoline (I) and of anthranilic acid are measured. Curves for the following derivatives of I acid are measured. Curves are given for the following derivatives of I: 2-oxo-, m. 263-5°, 1-methyl-2-oxo-, m. 288-90°, 3-phenyl-2-oxo-, m. 278°, 2-thio-, m.inst. 315°, 2-imino- m.inst. 310°, and 3-phenyl-2-thio-, m.inst. 307°; ο-H2NOCC6H4NHCONH2, m.inst. 218°; ο-MeO2CC6H4NHCONH2, m.inst. 350°; ο-MeO2CC6H4NHCSNH2, m.inst. 288°; and the following ο-substituted PhNHCONHPh: ο-CONH2, m.inst. 239°, ο-COOH, m.inst. 235°, ο-CO2Me, m. 143-4°, and ο-CN, m. 177°.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Using solid-state density functional theory and terahertz spectroscopy to spectroscopically distinguish the various hydrohalide salts of 5-(4-pyridyl)tetrazole, the main research direction is pyridyltetrazole hydrobromide hydrochloride solid state density functional far IR; crystal structure pyridyltetrazole hydrobromide hydrochloride; mol structure pyridyltetrazole hydrobromide hydrochloride; tetrazole pyridyl hydrobromide hydrochloride crystal mol structure far IR.Safety of 5-(4-Pyridyl)-1H-tetrazole.

The crystal structures and exptl. THz spectra of the isostructural hydrobromide and hydrochloride salts of 5-(4-pyridyl)tetrazole were reproduced using solid-state d. functional theory as implemented in CRYSTAL09. The effect of the halide size was studied to determine the influence on the low energy lattice and mol. vibrations exhibited at 10-100 cm-1, known as the terahertz (THz) region. Using solid-state DFT, the normal modes of these THz vibrations were determined and the mass and size of the halide anion has a significant effect in this region. A trend was observed in the frequencies in the terahertz region, such that increasing the mass of the anion, produces an overall red shift in the frequency. Crystallog. data are given.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14389-12-9, is researched, Molecular C6H5N5, about Safe and fast tetrazole formation in ionic liquids, the main research direction is carbonitrile azide cycloaddition ionic liquid; tetrazole preparation; ionic liquid cycloaddition solvent.Computed Properties of C6H5N5.

The [2 + 3]-cycloaddition of nitriles and azides is reliable for intramol. reactions, but the hazards with volatile azides in intermol. reactions are tremendous. Zinc catalysis in aqueous solution is a magnificent improvement, but requires the removal of the zinc salts from the acidic product. The use of safe solvents featuring low vapor pressure and good solubility of NaN3, is reported. Ionic liquids based on alkylated imidazoles combined with microwave heating turned out to be a solution for the given tasks.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C8H7N3O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.

QSAR anal. of triazines I (R = H, Br, F, I, Me, MeO, CF3, PhCH2O, etc.) and quinazolines II R = H, OH, SH, H2N, AcNH, Me, etc.; n = 1-3) as inhibitors of rat liver dihydrofolate reductase  [9002-03-3] using distance geometry anal. is described. The model was applied to predict the biol. activity of 91 compounds The predicted values showed a root mean square deviation of 0.907 and a correlation coefficient of 0.790. The distance geometry model for the dihydrofolate reductase inhibition is unique in its ability to fit 3 different sets of mols. (3′- and 4′-substituted phenyltriazines and quinazolines) in the same model, and successfully predicts the biol. activity of the compounds

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14389-12-9, is researched, Molecular C6H5N5, about Syntheses Study of Keggin POM Supporting MOFs System, the main research direction is preparation silver pyridyltetrazolate molybdate tungstate Keggin MOF; crystal structure silver pyridyltetrazolate molybdate tungstate Keggin MOF; luminescence silver pyridyltetrazolate molybdate tungstate Keggin MOF.Reference of 5-(4-Pyridyl)-1H-tetrazole.

To study the influence of reactive conditions on the structures of Keggin POM supporting metal-organic frameworks (MOFs), five new compounds, [Ag6(2-pytz)4(H2O)2][HPMo12O40] (1), {[Ag14(2-pytz)12(H2O)4][H2PMo12O40]2}·3H2O (2), {[Ag6(2-pytz)4(H2O)4][H2SiW12O40]}·6H2O (3), {[Ag3(3-pytz)2]2·[AgPMo12O40]}·2H2O (4), [Ag6(4-pytz)4][HPMo12O40] (5) [pytz = 5-(pyridyl)tetrazolate], were hydrothermally synthesized by tuning the reactive species and pH values and characterized by routine method and single-crystal x-ray crystallog. Although compounds 1-5 all show the POM supporting 3-dimensional MOFs skeleton, MOFs exhibit diverse structures and POMs play different supporting functions, more specifically, pseudo POM chains supporting MOFs in 1 and 2, isolated POM spheres supporting MOFs in 3, true POM chains supporting MOFs in 4, and pseudo POM layers supporting MOFs in 5. The roles of the pH value, pytz derivatives, and the Keggin homologs in the formation of the POM supporting MOFs are discussed. The photoluminescence properties of compounds 1-3 were studied in the solid state at room temperature

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis