Chiral nitrogen ligands

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 6-Chloro-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide, published in 2013-12-31, which mentions a compound: 6684-39-5, mainly applied to crystal structure chloropyridinylmethylpyridinesulfonamide; mol structure chloropyridinylmethylpyridinesulfonamide; hydrogen bond chloropyridinylmethylpyridinesulfonamide, COA of Formula: C5H3Cl2NO2S.

In 6-chloro-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide, C11H10ClN3O2S, the dihedral angle between the pyridine rings is 46.85(12)°. The N atom of the chloropyridine ring is anti to the N-H bond. In the crystal, mols. are linked through N-H···N H bonds into zigzag chains parallel to [001] with a C(7) graph-set motif. Crystallog. data are given.

After consulting a lot of data, we found that this compound(6684-39-5)COA of Formula: C5H3Cl2NO2S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

HPLC of Formula: 3411-48-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Rhodium catalyzed hydroformylation assisted by cyclodextrins in biphasic medium: Can sulfonated naphthylphosphanes lead to active, selective and recyclable catalytic species?. Author is Elard, Maxime; Denis, Julien; Ferreira, Michel; Bricout, Herve; Landy, David; Tilloy, Sebastien; Monflier, Eric.

New sulfonated naphthylphosphanes having an average sulfonation degree around 2 were synthesized and tested as ligand in the aqueous biphasic Rh-catalyzed hydroformylation of 1-decene assisted by randomly methylated β-cyclodextrins. All these water-soluble phosphanes associated to a rhodium precursor were able to perform aqueous hydroformylation of 1-decene. The best results in terms of catalyst recovery and recycling were obtained with sulfonated 2-naphthylphosphanes. With sulfonated 1-naphthylphosphanes, formation of low-coordinated catalytic species leading to a catalyst leaching in the organic phase was postulated. These results were rationalized by considering that sulfonated 1-naphthylphosphanes are bulkier ligands than sulfonated 2-naphthylphosphanes.

After consulting a lot of data, we found that this compound(3411-48-1)HPLC of Formula: 3411-48-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Electronic spectra of N-heteroaromatic systems. I. The n-π transitions of monocyclic azines》. Authors are Mason, S. F..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Synthetic Route of C8H7N3O. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

The positions and the intensities of the band in the visible and the ultraviolet spectra of monocyclic azines owing to the promotion of an electron from a lone-pair N orbital to a π-orbital of the ring have been measured in the vapor phase and in solution in cyclohexane (I) and H2O. The frequency of the band is determined primarily by the energy of the benzene-like lowest unoccupied π orbital of the azine and by groundstate interaction between lone-pair orbitals on different N atoms. The intensities of the n → π bands of the azines increase with the “”s”” character of the lone-pair N orbitals, but the frequencies of the bands are not greatly affected, owing to orbital-following in the transition. The frequencies (ν) in vapor, νmaximum in I, νmaximum in H2O, all oscillator strength (f) in I, and pKα are given for pyridine, pyrimidine, pyrazine, pyridazine, sym-triazine, 3,5,6-trimethyl-1,2,4-triazine, m-tetrazine.

After consulting a lot of data, we found that this compound(20198-19-0)Synthetic Route of C8H7N3O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of 2-Aminoquinazolin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Identification of the main nitrogen-containing compounds in Ctenopharyngodon idellus by HPLC-Q-TOF-MS. Author is Zhang, You-sheng; Huang, Jia-si; Liu, Xue-ming; Cheng, Jing-rong; Chen, Zhi-yi; Zhang, Ye-hui.

The main nitrogenous compounds in methanol extracts of Ctenopharyngodon idellus were analyzed and identified using high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). Both pos. and neg. ionization modes were used to confirm the related chem. compounds and their characteristic fragment ions according to the accurate mol. mass information of the excimer ion peaks and the fragment ions. Using the ChemSpider database, 33 nitrogenous compounds in Ctenopharyngodon idellus were ultimately determined, and the data for the main fragments of each component were analyzed. These 33 nitrogenous compounds included 11 amino acids (eight types of α-amino acids), 12 amines, eight amide compounds, and two heterocyclic nitrogenous compounds The results showed that the structures of monomer compounds in fresh aquatic products and raw materials could be elucidated directly using the HPLC-Q-TOF-MS technique and fragmentation anal. by mass spectrometry, which can improve the efficiency of anal. and identification of chem. components in fresh raw material. This study shows that these techniques are conducive for the identification and anal. of active components and newly generated compounds during the storage of fresh raw materials.

After consulting a lot of data, we found that this compound(20198-19-0)Application In Synthesis of 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Catalysis called Synthesis of Phosphinines from CoII-Catalyzed [2+2+2] Cycloaddition Reactions, Author is Glaesel, Tim; Jiao, Haijun; Hapke, Marko, which mentions a compound: 1663-45-2, SMILESS is P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4, Molecular C26H24P2, Name: 1,2-Bis(diphenylphosphino)ethane.

The CoII-catalyzed [2+2+2] cycloaddition of functionalized diynes and phosphaalkynes resulting in the formation of an array of structurally interesting phosphinines is reported. A combination of 1,2-bis(diphenylphosphino)benzene (dppbenz) and CoI2 turned out to be the most suitable and active catalyst system under microwave reaction conditions. Chemoselective cyclizations of phosphaalkynes in the presence of nitriles have been observed, and a number of carbonyl functionalities are tolerated as well. The reaction can successfully be conducted with a 1:1 ratio of phosphaalkyne/diyne substrate. Model reactions with benzonitrile and diyne demonstrated that CoII catalysts in the presence of bisphosphines prefer carbocyclization, while reduction to lower oxidation states promotes heterocyclization to the corresponding pyridine. A reaction mechanism comprising a CoII oxidation state for the cyclotrimerization process is proposed and rationalized based on control experiments and theor. calculations

After consulting a lot of data, we found that this compound(1663-45-2)Name: 1,2-Bis(diphenylphosphino)ethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Quality Control of Tri(naphthalen-1-yl)phosphine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about C-H Bond Activation by Radical Ion Pairs Derived from R3P/Al(C6F5)3 Frustrated Lewis Pairs and N2O. Author is Menard, Gabriel; Hatnean, Jillian A.; Cowley, Hugh J.; Lough, Alan J.; Rawson, Jeremy M.; Stephan, Douglas W..

Al(C6F5)3/R3P [R = tert-Bu (tBu), mesityl (Mes), naphthyl (Nap)] frustrated Lewis pairs react with N2O to form species having the formula R3P(N2O)Al(C6F5)3, which react with addnl. alane to generate proposed frustrated radical ion pairs formulated as [R3P·][(μ-O·)(Al(C6F5)3)2] that can activate C-H bonds. For R = tBu, C-H activation of a tBu group affords [tBu2PMe(C(CH2)Me)][(μ-OH)(Al(C6F5)3)2]. In the case of R = Mes, the radical cation salt [Mes3P·][(μ-HO)(Al(C6F5)3)2] is isolated, while for R = Nap, the activation of toluene and bromobenzene gives [(Nap)3PCH2Ph][(μ-OH)(Al(C6F5)3)2] and [(Nap)3PC6H4Br][(μ-HO)(Al(C6F5)3)2], resp.

After consulting a lot of data, we found that this compound(3411-48-1)Quality Control of Tri(naphthalen-1-yl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zeslawska, Ewa; Kucwaj-Brysz, Katarzyna; Kincses, Annamaria; Spengler, Gabriella; Szymanska, Ewa; Czopek, Anna; Marc, Malgorzata Anna; Kaczor, Aneta; Nitek, Wojciech; Dominguez-Alvarez, Enrique; Latacz, Gniewomir; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Quality Control of 1,5-Dibromopentane.They published the article 《An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: arylpiperazinyl spiroimidazolidinedione preparation docking antitumor crystal multidrug resistance lymphoma; Crystal structure; Fluorene; Hydantoin; Multidrug resistance; P-glycoprotein (ABCB1); T-lymphoma. We’ll tell you more about this compound (cas:111-24-0).

A series of arylpiperazine derivatives of the 5-spiroimidazolidine-2,4-diones I/I·HCl (n = 3, 4, 5; R = Ph, Bn, 4-nitrophenyl, diphenylmethyl, 3-chlorophenyl), II (m = 1, 2; R1 = H, CF3) and III has been explored, including variations in the number of aromatic rings at position 5 and the length of the linker, as well as the kind and position of the linked arylpiperazine terminal fragment. Synthesis I/I·HCl and X-ray crystallog. studies for representative compounds I (n = 4; R = Bn), I·HCl (n = 3, R = Bn; n = 5, R = Ph) and II (m = 2; R1 = H (III)) have been performed. The ability to inhibit the tumor multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells was investigated. The cytotoxic and antiproliferative actions of the compounds on both the reference and the ABCB1-overproducing cells were also examined The pharmacophore-based mol. modeling studies have been performed. ADMET properties in vitro of selected most active derivatives I (n = 4; R = 4-nitrophenyl) and I·HCl (n = 3, R = Ph; n = 4, R = diphenylmethyl (IV)) have been determined All compounds, excluding III, inhibited the cancer P-gp efflux pump with higher potency than that of reference verapamil. The spirofluorene derivatives with amine alkyl substituents at position 1, and the Me group at position 3 (I/I·HCl), occurred the most potent P-gp inhibitors in the MDR T-lymphoma cell line. In particular, compounds I·HCl (n = 3; R = 4-nitrophenyl) and IV were 100-fold more potent than verapamil. Crystallog.-supported pharmacophore-based SAR anal. has postulated specific structural properties that could explain this excellent cancer MDR-inhibitory action.

After consulting a lot of data, we found that this compound(111-24-0)Quality Control of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Carbonylation of organic halo derivatives into acids in the presence of palladium complexes, published in 1982-06-30, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, SDS of cas: 3411-48-1.

The reactions of organic halides with CO to give carboxylic acids were catalyzed by the reaction products of (PhCN)2PdCl2 (I) with different ligands, e.g., phosphines, stilbines, sulfides, and quinone. Tertiary phosphines, especially Ph3P, were the most effective ligands. The activity of the halides increased in the following orders: alkyl < Ph < benzyl and Cl < Br < I. With Ph3P and I the optimal P/Pd ratio was 4-6. After consulting a lot of data, we found that this compound(3411-48-1)SDS of cas: 3411-48-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Mechanistic Investigations of Reactions of the Frustrated Lewis Pairs (Triarylphosphines/B(C6F5)3) with Michael Acceptors. Author is Dupre, Jonathan; Gaumont, Annie-Claude; Lakhdar, Sami.

Frustrated Lewis pair (FLP)-catalyzed reduction of Michael acceptors is a challenging reaction that proceeds with specific FLP structures. Kinetics and equilibrium of the reactions of two phosphines (Ar3P), namely tri(1-naphthyl)phosphine and tri(o-tolyl)phosphine, are reported with reference electrophiles. The reason for the failure of the FLPs (Ar3P/B(C6F5)3) to reduce activated alkenes under H2 pressure is shown to be a hydrophosphination process that inhibits the reduction reaction. Kinetic and thermodn. factors controlling both pathways are discussed in light of Mayr’s free linear energy relationships.

After consulting a lot of data, we found that this compound(3411-48-1)Electric Literature of C30H21P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Quantitative structure-activity study of some enzyme-inhibitory quinazolines.Name: 2-Aminoquinazolin-4(3H)-one.

Relations are formulated to explain the variation in dihydrofolate reductase [9002-03-3] inhibitory potency for a series of 25 substituted quinazolines I(R = H, OH, NH2, AcNH; R1 = H, NH2, OH, SH; R2 = H, Cl, Me; R3 = H, Me, NH2, Cl, CN, CHO, Br, CH2NH2) with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2-3R calculated indexes and(or) the empirically estimated mol. polarizability as independent variables. The MO calculated indexes employed are the at. polarizability, as defined herein, and bond energy. The mol. polarizability is represented by a simple sum of environment-independent partial at. polarizabilities. The partial polarizabilities, reported here for H, C, N, O, F, S, Cl, and Br, are obtained from a multiple regression forced through the origin.

After consulting a lot of data, we found that this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis