Chiral nitrogen ligands

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine. A new synthetic method of this compound is introduced below. , 110-70-3

A mixture of 2-(3-bromo-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid (600 mg, 1.7 mmol), N,N’-dimethyl-ethane-1,2-diamine (0.37 mL, 3.4 mmol), copper(I) iodide (96 mg, 0.5 mmol), N,N-dimethylglycine hydrochloride (140 mg, 1.0 mmol) and potassium carbonate (923 mg, 6.7 mmol) in dimethyl sulfoxide (5 mL) was stirred at 120 C. for 16 h. Then the reaction mixture cooled to room temperature. The reaction mixture was extracted with ethyl acetate (2¡Á150 mL), washed with water (2¡Á50 mL) and saturated aqueous ammonium chloride solution (2¡Á50 mL), dried over anhydrous sodium sulfate and then concentrated in vacuo. Purification by Waters automated flash system (column: Xterra 30 mm¡Á100 mm, sample manager 2767, pump 2525, detector: ZQ mass and UV 2487, solvent system: acetonitrile and 0.1% ammonium hydroxide in water) afforded 3,3-dimethyl-2-{3-[methyl-(2-methylamino-ethyl)-amino]-phenyl}-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid (500 mg, 80%) as a white solid: LC/MS m/e calcd for C22H29N3O2 (M+H)+: 368.50, observed: 368.1.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of N1,N2-Dimethylethane-1,2-diamine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei; US2011/257151; (2011); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.31886-58-5, name is (R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, below Introduce a new synthetic route. , 31886-58-5

General procedure: 0C, N2,7 mL of tBuLi in n-hexane (1.6 mol/L, 11.2 mmol) was added dropwise with stirringCompound 1 (2.57 g, 10 mmol) in anhydrous ether (20 mL),After the addition, the mixture was naturally warmed to room temperature and stirred for 2 hours. Then cool down to -78C,The redistilled PCl3 (11.46 mmol, 1 mL) was slowly added dropwise, and the mixture was warmed to room temperature.The reaction was overnight. Then cool down to -78C again.A solution of R2MgBr (prepared from 30 mmol of R2Br and 0.8 g, 33.3 mmol of magnesium turnings in tetrahydrofuran) was slowly added dropwise using a constant pressure funnel. After the addition, slowly warm up the reaction overnight.Then 20 mL of saturated NH4Cl solution was added. The oil phase was extracted three times with 20 mL ether.After the oil phase was dried over anhydrous sodium sulfate, it was spin-dried, and the silica gel was subjected to a chromatography to obtain the target compound 2 .

31886-58-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,31886-58-5 ,(R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Kaitelisi (Shenzhen) Technology Co., Ltd.; Zhang Xumu; Liang Zhiqin; (17 pag.)CN107722068; (2018); A;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

110-70-3, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine. A new synthetic method of this compound is introduced below.

A single-neck RBFequipped with a magnetic stirrer was charged with methyl2-bromo-2-(4-nitrophenyl)acetate (3,7.33 g, 26.74 mmol) and EtOH (80 mL). After cooling to 0 C in an ice/waterbath. N,N?-dimethylethane-1,2-diamine (23 g, 0.26 mol) was added to the solution over 5 min. Theresulting solution was stirred at 0 C to 25 C overnight. After evaporation invacuo, the crude mixturewas purified on a silica gel column (MeOH: DCM = 10: 90) to afford compound 4 as a yellow solid (6.70 g, 100%).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of N1,N2-Dimethylethane-1,2-diamine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Young, Wendy B.; Barbosa, James; Blomgren, Peter; Bremer, Meire C.; Crawford, James J.; Dambach, Donna; Gallion, Steve; Hymowitz, Sarah G.; Kropf, Jeffrey E.; Lee, Seung H.; Liu, Lichuan; Lubach, Joseph W.; Macaluso, Jen; Maciejewski, Pat; Maurer, Brigitte; Mitchell, Scott A.; Ortwine, Daniel F.; Di Paolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Sowell, C. Gregory; Wang, Xiaojing; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Currie, Kevin S.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 6; (2015); p. 1333 – 1337;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

110-70-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine, below Introduce a new synthetic route.

Step 1 : To a solution of N,N’-dimethylethylenediamine (300 mg) in DMF (2.0 mL) was added K2C03 ( 1.0 g) and compound B (466 mg). The mixture was heated at 80C for 3h. Solvent was evaporated and the residue was extracted with DCM and then purified by a prep-TLC plate(10%MeOH/DCM with 1% NH3 in methanol) to give product as a yellow solid (400 mg, yield 75%).

110-70-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,110-70-3 ,N1,N2-Dimethylethane-1,2-diamine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; ARIAD PHARMACEUTICALS, INC.; DALGARNO, David, C.; HUANG, Wei-sheng; SHAKESPEARE, William, C.; WANG, Yihan; ZHU, Xiaotian; WO2012/151561; (2012); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.119139-23-0, 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, introduce a new downstream synthesis route. 119139-23-0

EXAMPLE 13 20 ml of a 1M solution of LiAlH4 in diethyl ether was added to a solution of 1.0 g of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione in 140 ml of THF. The mixture was stirred for 18 hours under nitrogen. The mixture was cooled to 0 C., quenched with 50 ml of water, then acidified to pH 2 with 2M hydrochloric acid and extracted with ethyl acetate. The organic extracts were washed with saturated sodium bicarbonate solution, dried and evaporated. The residue was purified on silica gel with 5-10% methanol in dichloromethane. The first product eluted was triturated with ethyl acetate/hexane to give 175 mg of 3,4-bis(3-indolyl)-3-pyrrolin-2-one, m.p. 290-293 C. (decomposition). The second product eluted was crystallized from ethyl acetate/chloroform to give 490 mg of 5-hydroxy-3,4-bis(3-indolyl)-3-pyrrolin-2-one, m.p. above 250 C. (decomposition).

119139-23-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119139-23-0 ,3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Hoffmann-La Roche Inc.; US5057614; (1991); A;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.31886-58-5, name is (R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, below Introduce a new synthetic route. , 31886-58-5

To a solution of 1.0 g (R)-Ugi amine (3.8 mmol) in dry DCM, 2 cm3 acetic acid anhydride (21 mmol) was added dropwise at room temperature.After 5 h, the reaction mixture was diluted with another portion of DCM (30 cm3) and washed with 5% NaHCO3(4 ¡Á 20 cm3). The collected organic layers were dried over MgSO4 and filtered, and the resulting solution was evaporated under reduced pressure to afford the crude product as an orange crystalline solid (1.04 g, 93%). M.p.: 70-72 C(lit. 70-71 C); 1H NMR (300 MHz, CDCl3):delta = 5.83 (q,J = 6.5 Hz, 1H), 4.29-4.19 (m, 2H), 4.15 (s, 3H), 1.56 (d,J = 6.5 Hz, 3H) ppm.

31886-58-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,31886-58-5 ,(R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Mravec, Bernard; Plevova, Kristina; ?ebesta, Radovan; Monatshefte fur Chemie; vol. 150; 2; (2019); p. 295 – 302;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine. Here is a downstream synthesis route of the compound 110-70-3, 110-70-3

General procedure: To a cooled to 0 C suspension consisting of N,N’-dimethyl-1,2-ethylenediamine (4.4 g, 0.05 mol), sodium bicarbonate (33.6 g, 0.40 mol), and CH2Cl2 (50 mL), a solution of 2-bromopropionyl chloride (1a) (25.7 g, 0.15 mol) in CH2Cl2 (40 mL) was added. The reaction temperature was maintained within 0-5 C and the addition time was 40 min. The mixture was stirred for 4 h at the same temperature. Water (130 mL) and CH2Cl2 (60 mL) were added and the organic layer was separated. The combined organic fractions were dried over sodium sulfate. The solvent was removed under reduced pressure. The residue was treated with hexane (30 mL) and a solid product was filtered off and recrystallized from diethyl ether to give pure compound 2a (13.25 g, 74%), m.p. 77.0-77.4 C (from diethyl ether).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 110-70-3, We look forward to the emergence of more reaction modes in the future.

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Article; Goncharova; Yakushchenko; Raevskaya; Yakushchenko; Konovalova; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 181 – 185; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 181 – 185,5;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

110-70-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine, below Introduce a new synthetic route.

The ligand L1 was synthesized via previously reported procedure[23]. A solution of potassium carbonate (2.55 g, 18.45 mmol)in 10 mL water was dropwise added to the aqueous solution of 2-(chloromethyl)-pyridine hydrochloride (1.5 g, 9.15 mmol in10 mL). After about 30 min. of stirring at room temperature, thereaction mixture was extracted with dichloromethane(3 20 mL). The combined organic extracts were dried over anhydroussodium sulfate. The solution was filtered and the solvent wasremoved under vacuum. The resulted residue was then dissolvedin dichloromethane (10 mL). The dichloromethane solution of 2-chloromethyl-pyridine was added dropwise to a solution of N,N0-dimethylethylenediamine (0.471 mL, 5.34 mmol) in dichloromethane(15 mL). After this addition, 10 mL of aqueous sodiumhydroxide (1 M) was added slowly and the reaction mixture wasstirred for next 60 h at room temperature. After stirring was finished,another fraction of sodium hydroxide (10 mL, 1 M) wasadded rapidly. The reaction mixture was extracted with dichloromethane(3 25 mL) and combined organic portion was dried overanhydrous sodium sulfate. Evaporation of solvent led to isolationof the ligand L1 as a dark orange oil. (1.13 g, Yield 79%) 1H NMR(500 MHz, Methanol-d4) d 7.27 (m, 2H, pyridine ring), 7.50 (d,2H, pyridine ring), 7.76 (m, 2H, pyridine ring), 8.45 (d, 2H, pyridinering), 3.68 (s, 4H, -N-CH2-Py), 2.63 (s, 4H, -CH2-CH2-), 2.26 (s, 6H,N-CH3). IR (cm1): 2945, 2789, 1589, 1569, 1472, 1432, 1360,1304, 1146, 1090, 1031, 994, 635, 614, 418.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of N1,N2-Dimethylethane-1,2-diamine, CAS: 110-70-3, you can also browse my other articles.

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Article; Singh, Nirupama; Niklas, Jens; Poluektov, Oleg; Van Heuvelen, Katherine M.; Mukherjee, Anusree; Inorganica Chimica Acta; vol. 455; (2017); p. 221 – 230;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

31886-58-5, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.31886-58-5, name is (R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, below Introduce a new synthetic route.

General procedure: To a solution of (R)-Ugi?s amine 3 (2.57 g, 10 mmol) in TBME (20 mL) was added 1.6 M t-BuLi solution in n-hexane (6.8 mL, 10.88 mmol) at 0 C. After the addition was complete, the mixture was warmed to room temperature, and stirred for 1.5 h at room temperature. The mixture was then cooled to 0 C again, and Ar2PCl (11 mmol) was added in one portion. After stirring for 20 min at 0 C, the mixture was warmed to room temperature, and stirred for 1.5 h at room temperature. The mixture was then quenched by the addition of saturated NaHCO3 solution (20 mL). The organic layer was separated and dried over MgSO4, and the solvent was removed under reduced pressure, after which the filtrate was concentrated. The residue was purified by chromatography to afford 4a, 4e, and 4f.

Thank you very much for taking the time to read this article. If you are also interested in other aspects of (R)-(+)-N,N-Dimethyl-1-ferrocenylethylamine, CAS: 31886-58-5, you can also browse my other articles.

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Article; Nie, Huifang; Zhou, Gang; Wang, Quanjun; Chen, Weiping; Zhang, Shengyong; Tetrahedron Asymmetry; vol. 24; 24; (2013); p. 1567 – 1571;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

110-70-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.110-70-3, name is N1,N2-Dimethylethane-1,2-diamine, below Introduce a new synthetic route.

To a solution of N,N’-dimethylethylenediamine (1.61 gram, 18.26 mmol) in methanol (20 mL) was added dropwise a solution of 2-pyridinecarboxaldehyde (1.96 gram, 18.29 mmol) in methanol (10 mL). The reaction mixture was stirred at room temperature for 1 hour forming an orange solution. NaCNBH3 (3.5 grams, 55.7 mmol) was added followed by addition of trifluoroacetic acid (5 mL), and the solution was stirred for additional 3 hours. After neutralization with NaOH 4M solution, the crude product was extracted with 3 portions of dichloromethane (30 mL). The collected organic layer was dried over Na2S04 and solvent was removed under vacuum yielding a yellow oil in 95 % yield. (0466) 1H NMR (CDC13, 500 MHz): delta 8.54 (ddd, 1H, J=4.85Hz, J=1.85Hz, J=0.85Hz, ArH), 7.65 (td, 1H, J=7.65Hz, J=1.82Hz, ArH), 7.40 (d, 1H, J=7.84Hz, ArH), 7.16 (ddd, 1H, J=7.65Hz, J=4.80Hz, J=1.0Hz, ArH), 3.67 (s, 2H, Ar-CH2), 2.70 (t, 2H, J=6.25Hz, CH2), 2.60 (t, 2H, J=6.16Hz, CH2), 2.42 (s, 3H, CH3), 2.28 (s, 3H, CH3). (0467) 13C NMR (CDC13, 125 MHz): delta 159.61 (C), 149.25 (CH), 136.60 (CH), 123.13 (CH), 122.14 (CH), 64.26 (CH2), 56.97 (CH2), 49.44 (CH2), 42.81 (CH3), 36.50 (CH3). (0468) MS (ESI): Calc for Ci0Hi7N3: 179.3, found: 180.3 (MH+).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of N1,N2-Dimethylethane-1,2-diamine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; RAMOT AT TEL-AVIV UNIVERSITY LTD.; KOL, Moshe; ROSEN, Tomer; POPOWSKI, Yanay; (87 pag.)WO2017/137990; (2017); A1;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis