7693-46-1, Name is 4-Nitrophenyl chloroformate, molecular formula is C7H4ClNO4, Recommanded Product: 7693-46-1, belongs to chiral-nitrogen-ligands compound, is a common compound. In a patnet, author is Ortiz, Aurelio, once mentioned the new application about 7693-46-1.
Syn-effect in asymmetric vinylogous alkylation of 3-[4-(N-phthalimide)-but-2-enoyl]oxazolidinone
An asymmetric vinylogous alkylation reaction of a N-enoyl oxazolidinone where an N-protected gamma-nitrogen atom is linked to the alpha,beta-unsaturated system is described. This reaction gave alpha-alkylated products in moderate yields and moderate diastereomeric ratios regarding the newly formed stereogenic center. Concomitantly, a deconjugated double bond was formed with a high Z-selectivity, thus representing a strong syn-effect. The removal of chiral oxazolidinone moiety and N-deprotection of amino group furnished a chiral alpha-substituted gamma-amino acid. [GRAPHICS] .
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis