Category: chiral-nitrogen-ligands

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,5-Dibromopentane( cas:111-24-0 ) is researched.Reference of 1,5-Dibromopentane.Qiu, Shaotong; Gao, Xiang; Zhu, Shifa published the article 《Dirhodium(II)-catalysed cycloisomerization of azaenyne: rapid assembly of centrally and axially chiral isoindazole frameworks》 about this compound( cas:111-24-0 ) in Chemical Science. Keywords: aromatic azaenyne dirhodium catalyst diastereoselective enantioselective regioselective cycloisomerization; aryl isoindazole preparation. Let’s learn more about this compound (cas:111-24-0).

A dirhodium(II)-catalyzed asym. cycloisomerization reaction of azaenynes through a cap-tether synergistic modulation strategy, which represents the first catalytic asym. cycloisomerization of azaenynes. This reaction is highly challenging because of its inherent strong background reaction leading to racemate formation and the high capability of coordination of the nitrogen atom resulting in catalyst deactivation. Varieties of centrally chiral isoindazole derivatives was prepared in up to 99 : 1 d.r., 99 : 1 er and 99% yield and diverse enantiomerically enriched atropisomers bearing two five-membered heteroaryls was accessed by using an oxidative central-to-axial chirality transfer strategy. The tethered nitrogen atom incorporated into the starting materials enabled easy late-modifications of the centrally and axially chiral products via C-H functionalizations, which further demonstrated the appealing synthetic utilities of this powerful asym. cyclization.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Al-Janabi, Emaad M. A.; Hatshan, Mohammad R.; Adil, Syed Farooq; Kadhum, Wesam R.; Al-Jibori, Subhi A.; Faihan, Ahmed S.; Al-Janabi, Ahmed S. researched the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2 ).Synthetic Route of C26H24P2.They published the article 《Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands》 about this compound( cas:1663-45-2 ) in Journal of Molecular Structure. Keywords: platinum diethyldithiocarbamate phosphine amine complex preparation antibacterial antitumor activity. We’ll tell you more about this compound (cas:1663-45-2).

A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3-6), [Pt(Et2DT)2(diamine)](7-8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental anal., conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr). Our interest in these types of complexes are based on the fact that these complexes are known for their promising biol. activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2μM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0μM.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,5-Dibromopentane( cas:111-24-0 ) is researched.Category: chiral-nitrogen-ligands.Shan, Naisong; Shen, Chengtian; Evans, Christopher M. published the article 《Critical Role of Ion Exchange Conditions on the Properties of Network Ionic Polymers》 about this compound( cas:111-24-0 ) in ACS Macro Letters. Keywords: ion exchange network ionic polymer. Let’s learn more about this compound (cas:111-24-0).

Ionic polymers are important in a wide range of applications and can exhibit widely different properties depending on the ionic species. In the case of single ion conducting polymers, where one charge is attached to the backbone or as a side group, ion exchange is performed to control the mobile species. While the conditions are often specified, the final ion content is not always quantified and there are no clear criteria for what concentration of salt is needed in the exchange. A series of ammonium network ionic polymers with different precise carbon spacers (C4-C7) between ionic junctions was synthesized as a model system to understand how ion exchange conditions impact the resultant polymer properties. The initial networks with free bromide anions were exchanged with 1.5, 3, or 10 equiv of lithium bis(trifluoromethane) sulfonimide (LiTFSI) salt in solution For networks with seven carbons between crosslinks, increasing the LiTFSI concentration lead to an increase in ion exchange efficiency from 83.7 to 97.6 mol %. At the highest conversion, the C7 network shows a 4°C decrease in glass transition temperature, 50°C increase in degradation temperature, 12-fold lower water uptake from air, and greater than 10-fold increase in conductivity at 90°C. These results illustrate that properties such as Tg are less sensitive to residual ion impurities, while conductivity is highly dependent on the final exchange conversion.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Category: chiral-nitrogen-ligands. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-Catalyzed Coupling of Optically Active Amines with Aryl Bromides. Author is Wagaw, Seble; Rennels, Roger A.; Buchwald, Stephen L..

The coupling of enantiomerically enriched amines with aryl bromides produces the corresponding N-aryl derivatives The choice of ligand in the palladium-catalyzed coupling is critical to the formation of the anilines without loss of enantiomeric purity. While LnPd [L = P(o-tolyl)3] successfully catalyzes the intramol. aryl amination of α-substituted optically pure amines, intermol. coupling reactions with this catalyst system gives racemized products. In contrast, intermol. N-arylations employing LnPd [L = (±)-BINAP] gives products in good yields with no erosion of enantiopurity. A mechanism for the observed racemization is proposed. The utility of the intramol. process is demonstrated by the synthesis of 3, an intermediate in the formal synthesis of 4, a potent ACE inhibitor.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Tripuramallu, Bharat Kumar; Manna, Paulami; Das, Samar K. published an article about the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9,SMILESS:C1(C2=NN=NN2)=CC=NC=C1 ).SDS of cas: 14389-12-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:14389-12-9) through the article.

Herein we report 6 new coordination polymers [Co(1,2-pda)(1,2-bix)]n, [Co(hfipbb)(1,2-bix)]n.nH2O, [Co(ADA)(1,2-bix)]n, [Co(ADA)(1,3-bix)]n.nH2O, [Co(1,4-pda)2(2-pztz)]2[Co(H2O)6].2nH2O, [Co2(μ-OH)(1,3-pda)(4-ptz)]n based on the flexible carboxylate ligands 1,2-phenylenediacetic acid (1,2-H2pda), 1,3-phenylenediacetic acid (1,3-H2pda), 1,3-adamantanediacetic acid (H2ADA), 4,4′-(hexafluoroisopropylidene)bis(benzoic acid) (H2hfipbb) and secondary N-donor ligands 1,3-bis(imidazole-1-ylmethyl)-benzene (1,3-bix), 1,2-bis(imidazole-1-ylmethyl)-benzene (1,2-bix), 5-(4-pyridyl)tetrazole (4-ptz), and 2-(2H-tetrazol-5-yl)pyrazine (2-pztz). All the compounds were characterized by single crystal x-ray diffraction anal., IR spectroscopy, elemental anal. and bulk homogeneity by powder x-ray diffraction. A subtle relation between the position of the coordinating groups in the linker (known as linker coordination angle, LCA) and the dimensionality and topol. of the final architectures of the title compounds was discussed systematically by comparing with the structurally related reported compounds [Co(1,4-pda)(1,4-bix)]n, [Co(hfipbb)(1,4-bix)0.5]n, and [Co2 (μ-OH)(1,4-pda)(4-ptz) ]n.nH2O. The compounds studied are classified into four different mixed linker classes, based on the skeleton geometry of the linker. Finally, temperature dependent magnetic susceptibility measurements were studied and the relevant zero-field splitting parameters were determined

As far as I know, this compound(14389-12-9)SDS of cas: 14389-12-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Science called Activation of apoptosis by rationally constructing NIR amphiphilic AIEgens: surmounting the shackle of mitochondrial membrane potential for amplified tumor ablation, Author is Li, Haidong; Lu, Yang; Chung, Jeewon; Han, Jingjing; Kim, Heejeong; Yao, Qichao; Kim, Gyoungmi; Wu, Xiaofeng; Long, Saran; Peng, Xiaojun; Yoon, Juyoung, which mentions a compound: 111-24-0, SMILESS is BrCCCCCBr, Molecular C5H10Br2, Application of 111-24-0.

In recent years, the use of aggregation-induced emission luminogens (AIEgens) for biol. imaging and phototherapy has become an area of intense research. However, most traditional AIEgens suffer from undesired aggregation in aqueous media with ′always on′ fluorescence, or their targeting effects cannot be maintained accurately in live cells with the microenvironment changes. These drawbacks seriously impede their application in the fields of bio-imaging and antitumor therapy, which require a high signal-to-noise ratio. Herein, we propose a mol. design strategy to tune the dispersity of AIEgens in both lipophilic and hydrophilic systems to obtain the novel near-IR (NIR, ∼737 nm) amphiphilic AIE photosensitizer (named TPA-S-TPP) with two pos. charges as well as a triplet lifetime of 11.43 μs. The synergistic effects of lipophilicity, electrostatic interaction, and structure-anchoring enable the wider dynamic range of AIEgen TPA-S-TPP for mitochondrial targeting with tolerance to the changes of mitochondrial membrane potential (Δψm). Intriguingly, TPA-S-TPP was difficult for normal cells to be taken up, indicative of low inherent toxicity for normal cells and tissues. Deeper insight into the changes of mitochondrial membrane potential and cleaved caspase 3 levels further revealed the mechanism of tumor cell apoptosis activated by AIEgen TPA-S-TPP under light irradiation With its advantages of low dark toxicity and good biocompatibility, acting as an efficient theranostic agent, TPA-S-TPP was successfully applied to kill cancer cells and to efficiently inhibit tumor growth in mice. This study will provide a new avenue for researchers to design more ideal amphiphilic AIE photosensitizers with NIR fluorescence.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-Catalyzed Cross-Coupling of N-Sulfonylaziridines and Alkenylboronic Acids: Stereospecific Synthesis of Homoallylic Amines with Di- and Trisubstituted Alkenes. Author is Teh, Wei Pin; Michael, Forrest E..

A palladium-catalyzed cross-coupling of 2-alkylaziridines with alkenylboronic acids to give homoallylamines, e.g., I, is presented. The reaction is highly regioselective and stereospecific and provides convenient access to enantioenriched amines with 1,1-disubstituted, 1,2-disubstituted, and trisubstituted alkenes. The modular synthesis of a 2,5-disubstituted pyrrolidine natural product I (ant venom alkaloid) was completed in three steps and 67% overall yield.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Article, Inorganic Chemistry called A Highly Connected Trinuclear Cluster Based Metal-Organic Framework for Efficient Separation of C2H2/C2H4 and C2H2/CO2, Author is Li, Qian; Wu, Nana; Li, Jia; Wu, Dapeng, the main research direction is cobalt MOF preparation acetylene adsorption separation ethylene carbon dioxide; crystal structure cobalt dihydroxybenzenedicarboxylate pyridyltetrazolate MOF trinuclear cluster.Formula: C6H5N5.

One of the barriers for efficient gas separation is the trade-off between the selectivity and adsorption capacity. To address this issue, the authors synthesized an anionic trinuclear CoII based 3-dimensional MOF (NH4)[Co3(OH)(4-Ptz)3(DOBDC)1.5]·3EtOH·2.5H2O (NbU-8, DOBDC = 2,5-dioxido-1,4-benzenedicarboxylate, HPtz = 5-(4-pyridyl)tetrazolate), which was characterized by an ultramicroporous building unit (UBU) and Lewis basic binding sites on the pore surfaces. Remarkably, the combination of the two strategies can synergistically enhance the C2H2 adsorption capacity (182.9 cm3/g at 298 K) and simultaneously achieve a high separation performance toward C2H2/C2H4 and C2H2/CO2 mixtures Besides theor. calculations, the separation efficiencies of C2H2/C2H4 and C2H2/CO2 are also demonstrated using breakthrough experiments D. functional theory calculations further confirmed the -OH groups and ultramicroporous building units play an important synergistic effect in efficiently capturing acetylene mols. Through a synergy strategy, a highly connected trinuclear CoII based metal-organic framework (NbU-8) was synthesized. It shows an excellent separation performance toward C2H2/C2H4 and C2H2/CO2, which is proved by breakthrough experiments and d. functional theory calculations

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Effect of various parameters on the stereoselectivity of 1,3-diene synthesis by carbopalladation of allenes, published in 1992, which mentions a compound: 3411-48-1, mainly applied to carbopalladation allene stereochem; diene stereoselective preparation; palladium pi allyl intermediate, Recommanded Product: 3411-48-1.

The effects of the temperature and of the nature of solvent, phosphine ligand and carbon nucleophile on the stereoselectivity of the palladium-catalyzed process involving 1,2-decadiene and vinyl bromide and leading to 1,3-dienes, e.g., (E)- and (Z)-CH2:CMeC(:CHR)CH2CH(CO2Et)2 (R = heptyl), have been studied. This reaction, which produces a 1:1 mixture of dienes in the conditions previously described [THF, Pd(dppe) (dppe = Ph2PCH2CH2PPh2), malonate anion] can be oriented either towards the E-isomer (75%) by using acetonitrile or a hindered phosphine or towards the Z-isomer (83%) when an anion of low nucleophilicity is involved. These results can be related to the relative stability and reactivity of both syn- and anti-π-allyl complexes which are intermediates in the process.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

SDS of cas: 1663-45-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Chiral expression of co-crystallizing poly(thiophene)-block-poly(selenophene) copolymers. Author is Timmermans, Birgitt; Koeckelberghs, Guy.

In this report, the chiral expression of co-crystallizing conjugated poly(thiophene)-b-poly(selenophene) copolymers is investigated. For this purpose, different poly(thiophene)-b-poly(selenophene) copolymers were synthesized via controlled Kumada catalyst transfer condensative polymerization (KCTCP). The homopolymers, poly(thiophene) and poly(selenophene), are synthesized as a reference Solvatochromism experiments were conducted to investigate the (chiral) self-assembly of all the polymers using UV-vis and CD (CD) spectroscopy. It was found that, although the chiral homopoly(selenophene) surprisingly did not self-assemble in a chiral way, the block copolymers did show a chiral expression. This can only be explained by the suggested co-crystallization of the block copolymers, since for (micro)phase-separating block copolymers no chiral expression would be expected, as the first aggregating block, in this case the poly(selenophene) block, then would dictate its stacking to the second block. Differential scanning calorimetry (DSC) further suggested the co-crystallization of the block copolymers. Moreover, the chiral expression of the poly(thiophene)-b-poly(selenophene) copolymers was even larger than for the homopoly(thiophene), which can be explained by the increased disorder present in the block copolymers. Dynamic light scattering (DLS) eliminated the existence of a correlation between the chiral response and the size of the polymer aggregates, further evidencing that the increase in the chiral response of the block copolymers is solely due to the suggested co-crystallization of the block copolymers.

As far as I know, this compound(1663-45-2)SDS of cas: 1663-45-2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis