Category: chiral-nitrogen-ligands

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zeitschrift fuer Anorganische und Allgemeine Chemie called Direct Synthesis and Characterization of New Copper(II) and Zinc(II) 5-R-Tetrazolato Complexes [R = Me, Ph, 4-Py] with Ethylenediamine and DMSO as Coligands, Author is Mosalkova, Anastasiya P.; Voitekhovich, Sergei V.; Lyakhov, Alexander S.; Ivashkevich, Ludmila S.; Gaponik, Pavel N.; Ivashkevich, Oleg A., which mentions a compound: 14389-12-9, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5, Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole.

Three novel 5-R-tetrazolato complexes (R = Me, Ph, 4-Py), [Zn2(MeCN4)4(DMSO)2]n (1), [Cu2(PhCN4)4(en)2]·2DMSO (2), and {[Cu(4-PyCN4)2(DMSO)2]·4DMSO}n (3), were isolated as unexpected products under attempts to prepare heterometallic tetrazolates using a direct synthesis strategy in the Cu0-ZnO-en-RCN4H-DMSO system (en = ethylenediamine). The prepared compounds were characterized by elemental, single-crystal x-ray, and thermal analyses, and IR spectroscopy. Variation of the 5-substituent of the tetrazole ring causes different composition of complexes 1-3 and diverse coordination modes of 5-R-tetrazolato ligands. Complex 1 is a 3-dimensional coordination polymer due to N1,N4-bridging of 5-methyltetrazolato anions. Complex 2, with en as a coligand, has a dinuclear structure with two copper atoms linked together by two 5-phenyltetrazolato ligands by tetrazole N2,N3 bridges. Complex 3 represents a 2-dimensional coordination polymer, formed due to 5-(4-pyridyl)tetrazolato bridges between adjacent copper atoms (with the tetrazole and pyridine rings nitrogen atoms as coordination centers). DMSO mols., included in all the compounds, are solvate and/or coordinated ones.

When you point to this article, it is believed that you are also very interested in this compound(14389-12-9)Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Al-Jibori, Subhi A.; Al-Doori, Luma A.; Al-Janabi, Ahmed S. M.; Alheety, Mustafa A.; Wagner, Christoph; Karadag, Ahmet published the article 《Mercury(II) mixed ligand complexes of phosphines or amines with 2-cyanoamino thiophenolate ligands formed via monodeprotonation and carbon-sulfur bond cleavage of 2-aminobenzothiazole. X-ray crystal structures of [Hg(SC6H4NCN)(PPh3)]2 and [Hg(SC6H4NCN)(Ph2PCH2PPh2)]2》. Keywords: mercury phosphine amine cyanoaminothiophenolate complex preparation crystal structure.They researched the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2 ).Formula: C26H24P2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1663-45-2) here.

The addition of sodium hydroxide to a mixture of Ph mercury acetate and 2-aminobenzothiazole in warm ethanol led to the high yield (84%) formation of [Ph-Hg(LH)]n (1), LH = the 2-cyanoaminothiaphenolate anion (SC6H4NHC[n.58118]N)-, resulting from monodeprotonation of 2-aminobenzothiazole and facile carbon-sulfur bond breakage. Reaction of 1 with Ph3P or Ph3PS afforded [Hg(LH)2(Ph3P)2] (2) or [PhHg(μ-LH)(Ph3PS)]2 (3), resp. Recrystallization of 2 from warm DMSO afforded [Hg(μ-L)(PPh3)]2 (4), L = the 2-cyanoaminothiophenolate di-anion (SC6H4NC[n.58118]N)2-, which was characterized by an x-ray diffraction study. Treatment of 1 with the diphosphines Ph2P(CH2)nPPh2, 2,6-diaminopyridine (dapy), ethylenediamine (en) or 1,10-phenanthroline (phen) afforded [PhHg(LH){ Ph2P(CH2)nPPh2}], {n = 1 dppm (5), n = 2 dppe (6), n = 3 dppp (7), n = 4 dppb (8), (CH2)n = (Cp)2Fe dppf (9)}, [PhHg(LH)(dapy)2] (11), [PhHg(LH)(en)] (12) or [PhHg(LH)(phen)] (13). Recrystallization of 5 from CH2Cl2 afforded binuclear [Hg(μ-L)(η1-dppm)]2.CH2Cl2 (10), which was characterized by an x-ray diffraction study.

When you point to this article, it is believed that you are also very interested in this compound(1663-45-2)Formula: C26H24P2 and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called An arene-stabilized η5-pentamethylcyclopentadienyl antimony dication acts as a source of Sb+ or Sb3+ cations, Author is Zhou, Jiliang; Kim, Hyehwang; Liu, Liu Leo; Cao, Levy L.; Stephan, Douglas W., which mentions a compound: 1663-45-2, SMILESS is P(CCP(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4, Molecular C26H24P2, Reference of 1,2-Bis(diphenylphosphino)ethane.

Double chloride abstraction from Cp*SbCl2 (Cp* = pentamethylcyclopentadienyl) affords an arene-stabilized η5-Cp*-bound antimony dicationic compound [(η5-Cp*)Sb(tol)][B(C6F5)4]2 (1) (tol = toluene), which exhibits strong Lewis acidity, abstracting chloride from Ph3CCl. 1 Reacts with different Lewis bases via divergent pathways, giving rise to release of either Sb+ or Sb3+ cations.

When you point to this article, it is believed that you are also very interested in this compound(1663-45-2)Reference of 1,2-Bis(diphenylphosphino)ethane and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Complexes of gold(I) and platinum(II) with polyaromatic phosphine ligands.Synthetic Route of C30H21P.

Au and Pt(II) complexes of the phosphine ligands PArnPh3-n (Ar = naphthyl, anthracenyl, ferrocenyl and other polyaromatic groups) were synthesized. The electron donating abilities of naphthyl and anthracenyl phosphine ligands was explored using gas phase photoelectron spectral data on the parent phosphines and their relative complexing ability to Pt precursor mols. was assessed by synthetic studies and NMR experiments Their steric parameters were estimated by the Tolman cone angle methodol. using x-ray crystallog. data. The mol. structures of the Au complexes [AuCl(PAn2Ph)]·CHCl3 and [Au(PFc2Ph)2]·CHCl3 were determined

When you point to this article, it is believed that you are also very interested in this compound(3411-48-1)Synthetic Route of C30H21P and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO2F2) as fluoride provider, published in , which mentions a compound: 6684-39-5, Name is 2-Chloro-5-pyridinesulfonyl chloride, Molecular C5H3Cl2NO2S, Quality Control of 2-Chloro-5-pyridinesulfonyl chloride.

A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO2F [Ar = 4-MeC6H4, 4-PhC6H4, 4-ClC6H4, etc.] was developed from aryl sulfonyl chlorides using SO2F2 as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol.

When you point to this article, it is believed that you are also very interested in this compound(6684-39-5)Quality Control of 2-Chloro-5-pyridinesulfonyl chloride and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Formula: C26H24P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Synthesis of ruthenium-dithiocarbamate chelates bearing diphosphine ligands and their use as latent initiators for atom transfer radical additions. Author is Aldin, Mohammed Zain; Zaragoza, Guillermo; Delaude, Lionel.

Nine representative [Ru(S2CNEt2)2(diphos)] complexes were prepared in almost quant. yields (91-97%) from [RuCl2(p-cymene)]2, Na diethyldithiocarbamate trihydrate, and a diphosphine (dppm, dppe, dppp, dppb, dpppe, dppen, dppbz, dppf, or DPEphos), using a novel, straightforward, 1-pot procedure. The recourse to a monomodal microwave reactor was instrumental in reaching the thermodn. equilibrium favoring the targeted monometallic trichelates. All the products were fully characterized by using various anal. techniques and the mol. structures of seven of them were determined by x-ray crystallog. NMR, XRD, and IR spectroscopies evidenced a significant contribution of the thioureide resonance form Et2N+:CS2-2 to the electronic structure of the 1,1-dithiolate ligand. MS/MS spectrometry showed the formation of phosphine-free [Ru(S2CNEt2)2]+ cations in the gas phase, except when starting from [Ru(S2CNEt2)2(dppbz)]. The activity of the nine complexes was probed in three different catalytic processes, viz., the cyclopropanation of styrene with Et diazoacetate, the synthesis of vinyl esters from HOBz and 1-hexyne, and the atom transfer radical addition (ATRA) of CCl4 and Me methacrylate. In the 1st two reactions, the saturated trichelates were poorly efficient. This was most likely due to their high stability, which prevented the formation of coordinatively unsaturated species. Contrastingly, with a turnover number of 2000 and an initial turnover frequency of 2080 h-1 for a 0.05 mol% catalyst loading, the [Ru(S2CNEt2)2(dppm)] complex emerged as a very robust, latent ATRA initiator, whose activity matched or outperformed those displayed by the most efficient Ru catalysts described so far.

When you point to this article, it is believed that you are also very interested in this compound(1663-45-2)Formula: C26H24P2 and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ) is researched.Computed Properties of C6H5N5.Song, Wei-Chao; Pan, Qinhe; Song, Peng-Chao; Zhao, Qiang; Zeng, Yong-Fei; Hu, Tong-Liang; Bu, Xian-He published the article 《Two unprecedented 10-connected bct topological metal-organic frameworks constructed from cadmium clusters》 about this compound( cas:14389-12-9 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: unprecedented ten connected bct organic framework cadmium cluster preparation; cadmium isophthalic acid pyridyl tetrazole metal organic framework preparation; crystal mol structure cadmium isophthalic acid pyridyl tetrazole cluster. Let’s learn more about this compound (cas:14389-12-9).

By simply modifying the expansion of ligand tether length, two Cd(ii) metal-organic frameworks have been constructed from linear tetranuclear and trinuclear cadmium clusters, resp., which present an unprecedented 10-connected unimodal bct net.

When you point to this article, it is believed that you are also very interested in this compound(14389-12-9)Computed Properties of C6H5N5 and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3411-48-1, is researched, SMILESS is C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2, Molecular C30H21PJournal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Regioselective trans-Carboboration of Propargyl Alcohols, Author is Jin, Hongming; Fuerstner, Alois, the main research direction is regioselective trans carboboration propargyl alc; crystal mol structure dioxaborolanyl butenol hexenol boracycle.Name: Tri(naphthalen-1-yl)phosphine.

Proper choice of the base allowed trans-diboration of propargyl alcs. with B2(pin)2 to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, Me, allyl, benzyl, alkynyl), which is invariably placed distal to the -OH group.

When you point to this article, it is believed that you are also very interested in this compound(3411-48-1)Name: Tri(naphthalen-1-yl)phosphine and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Cyclic amidines. X. 2-Aminoquinazoline derivatives》. Authors are Grout, R. J.; Partridge, M. W..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Name: 2-Aminoquinazolin-4(3H)-one. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

cf. CA 54, 3439a. 2-(Substituted amino)- and 3-substituted 2-aminoquin-azolines were produced by interaction of a urea, an arenesulfonyl chloride, and Me anthranilate (I). Rearrangements of 3-substituted 2-amino-3,4-dihydro-4-oxoquinazolines to their 2-(substituted amino)isomers, aminolyzes, alkylations, and transalkylations of quinazoline derivatives were examined None of the compounds reported was of therapeutic interest. EtNHCONH2 (8.8 g.) suspended in 30 mL. C5H5N treated during 10 min. at 0° with 17.7 g. PhSO2Cl, the mixture kept overnight at 0°, and heated 4 h. with 15.1 g. I gave 6.1 g. 4-hydroxyquinazolinium chloride, m. 293° (decomposition) (EtOCH2CH2OH). The free base m. 232° (Me2CO); picrate m. 274-5° (decomposition) (AcOH); acetyl derivative, prisms, m. 121-2° (C6H6-ligroine). The C5H5N mother liquor from the isolation of the foregoing chloride evaporated, and the residue codistd. with 130 mL. NH4OH gave 3 g. 4-oxoquinazoline, prisms, m. 186-7° (H2O); picrate, prisms, m. 282-4° (decomposition); acetyl derivative, prisms, m. 158-9° (C6H6-ligroine). The following 4-hydroxy-2-substituted-aminoquinazolines were thus obtained (substituent, m.p., % yield, m.p. of picrate, and m.p. of Ac derivative given): Me, 276°, 7, 294°, 196°; Pr, 198.5-200°, 34 (0.5HCl salt m. 292.5-3.5°) 252°, 118-19°; iso-Pr, 212-13°, 45, 264°, 129-30°; Bu, 187-8°, 39 (0.5HCl salt m. 258-9°), 240°; 111-12°; Me(CH2)4, 157.5-9.0°, 40 (0.5HCl salt m. 235°) 215-16°, 60-2°; cyclohexyl, 209-10°, 58 (0.5HCl salt m. 283°) 267°, 204-5°; PhCH2, 213.5-14.5°, 49, 236°, 124-5°; Ph, 261°, 19, 268°, 202-4° p-C6H4Me, 268-9°, 32, semipicrate, 285°; 209°; o-C6H4Me, 287-9°, 41, 255-6°, 154-6°; p-MeOC6H4, 271-2°, 36, -, 204-5°. The following 2-amino-3,4-dihydro-3-substituted-4-oxoquinazolines were thus obtained [3-substituent, m.p., % yield, m.p. of picrate, and m.p. of Ac derivative given]: Me, 242°, 46, 282-3°, 156-7°; Pr, 186-8°, 16.5, 261°, 151-2°; Bu, 192°, 11, 228-9°, acetyl, 140-1°; Me(CH2)4, 177°, 16, 250°, 96°; PhCH2, 202-4°, 9, 270°, 189-90°; Ph, 252°, 23 (HCl salt m. 291-2°), 268-9°; diacetyl, 209°; p-MeOC6H4, 234-6°, 5 (p-toluenesulfonate m. 258-9°), 271-2°; diacetyl, 206-8°. Pentylamine (17.4 g.) in 20 mL. concentrated HCl and 50 mL. H2O treated with 13 g. NaOCN in 100 mL. H2O gave 17.5 g. pentylurea, b17 137-9°; oxime, m. 102°. Methylphenylcyanamide (3 g.) and 7.4 g. o-methoxycarbonylanilinium p-toluenesulfonate in aqueous alkali heated 2 h. at 210° gave 1.3 g. 4-hydroxy-2-N-methylanilinoquinazoline, prisms, m. 197.5-8.5°; p-toluenesulfonate, prisms, m. 173-4° (alc.-Et2O). p-Methoxyphenylcyanamide (9.8 g.) and 11.4 g. 2-diethylaminoethyl chloride HCl salt refluxed 1 h. in 150 mL. alc. containing 3 g. Na gave 11.3 g. (2-diethylaminoethyl)-p-methoxyphenylcyanamide, m. 31-3°, b4 184°, and 1.4 g. tri-p-methoxyphenylisomelamine, m. 212°. 2-Chloro-4-ethoxyquinazoline (II) and PhNHMe refluxed 1 h. in alc. gave 4-ethoxy-2-N-methylanilinoquinazoline, prisms, m. 87-8° (ligroine); picrate m. 189-90° (decomposition). II (2.3 g.) and 1.2 g. p-anisidine refluxed 1 h. in 20 mL. alc. gave 2.9 g. 2-p-anisidino-4-ethoxyquinazoline, prisms, m. 98-9° (ligroine); picrate m. 179-80° (Me2CO). PhSO2Cl (17.7 g.) added at 0° to 19.4 g. o-ureidobenzoate suspended in 30 mL. C5H5N, and kept overnight at 0° gave 4.9 g. Me o-cyanamidobenzoate, m. 105-6° and 3.5 g. 2,4-dihydroxyquinazoline, m. 349-50°. The alkali insoluble fraction yielded 8.1 g. Me o-benzenesulfonylcyanamidobenzoate, prisms, m. 108° (iso-PrOH). 2-Amino-3,4-dihydro-4-oxo-3-phenylquinazoline (1 g.) refluxed 8 h. with 20 mL. 10N NaOH and the Na salt decomposed with AcOH gave 1 g. 2-anilino-4-hydroxyquinazoline (III), m. 261°; acetyl derivative, m. 202-4°. III was formed in 74% yield when 2-amino-4-hydroxyquinazoline (IIIa) was refluxed 24 h. with 10 mol PhNH2. The following quinazolines were similarly produced by analogous rearrangements and identified by comparison of the base and appropriate derivative with known compounds: 4-hydroxy-2-methylamino-, 95%; 2-ethylamino-4-hydroxy-, 75%; 4-hydroxy-2-propylamino-, 50%; 2-benzylamino-4-hydroxy-, 11%; 4-hydroxy-2-p-methoxyanilino-, 100%, also produced by refluxing 4-ethoxy-2-(p-methoxyanilino-) quinazoline 5 h. with 3N HCl. o-Methoxycarbonylanilinium p-toluenesulfonate (32.3 g.) and 19 g. p-MeC6H4SO3H refluxed 3 h. with 8.4 g. dicyandiamide and 200 mL. H2O gave 15.3 g. p-toluenesulfonate, m. 291-2°. This salt gave 2-guanidino-4-hydroxyquinazoline (IV), m. 310-11° (decomposition). IV (2 g.) refluxed 2 h. with 4 g. KOH in 20 mL. (CH2OH)2, diluted with H2O, and neutralized gave 1.3 g. IIIa, m. 315° (decomposition); picrate m. 258-60° (decomposition); acetyl derivative m. 277-80° (EtOCH2CH2OH). Anthranilic acid (137 g.) in 93 mL. concentrated HCl and 1 l. H2O kept 7 wk with cyanamide gave 86 g. IIIa. IIIa (6.4 g.) and 5.4 g. 2-chloroethyl acetate refluxed 45 min. in 100 mL. alc. containing 0.92 g. Na and 0.6 g. NaI, and left overnight gave 0.8 g. 2-amino-3,4-dihydro-3-(= 2-hydroxyethyl)-4-oxoquinazoline, prisms, m. 224° (alc.); picrate m. 220-1°. CH2ClCH2OH did not effect alkylation. Attempted alkylation of 2-acetamido-4-hydroxyquinazoline with 2-chloroethyl acetate gave only 93% IIIa. 4-Hydroxy-2-methylthioquinazoline (3.8 g.) and 4.6 g. 2-diethylaminoethylamine heated 75 min. at 180° gave 4.1 g. 2-(2-diethylaminoethylamino)-4-hydroxyquinazoline, m. 94-6° (aqueous alc.); picrate m. 234-5° (decomposition); MeI derivative, needles, m. 191-2°; methopicrate, needles, m. 194-5° (H2O). IIIa (3.2 g.) and 12.2 g. ethanolamine refluxed together 6 h. gave 1.15 g. 4-hydroxy-2-(2-hydroxyethylamino)quinazoline, m. 249.5-50.0° (H2O); picrate, needles, m. 212-13° (AcOH). A basic byproduct (1.65 g.), possibly 2,4-bis(2-hydroxyethylamino)quinazoline, crystallized from H2O as prisms, m. 162-3°; picrate m. 226-9° (alc.). Butylamine p-toluenesulfonate prepared in iso-PrOH gave needles, m. 122° (EtOAc). 2-Anilino-4-ethoxyquinazoline (IVa) (2.7 g.) refluxed 1 h. in 30 mL. BuOH containing 0.23 g. Na and poured into H2O gave 2.4 g. 2-anilino-5-butoxyquinazoline (V), prisms, m. 82-3° (alc.); picrate m. 182-3°(alc.). Crude 2-anilino-4-chloroquinazoline (1.1 g.) formed from 2-anilino-4-hydroxyquinazoline and POCl3, furnished 0.2 g. V, when refluxed 16 h. with 25 mL. BuOH containing 0.1 g. Na. IVa (5 g.) afforded 2 g. V, when refluxed 16 h. with 5 g. BuBr in 60 mL. alc. and 0.5 g. Na. The following ethers were obtained by transalkylation similar to that described above: 2-anilino-4-pentyloxyquinazoline (70%), needles, m. 118-19° (iso-PrOH), picrate m. 215-16° (decomposition) and 2-anilino-4-benzyloxyquinazoline (78%), needles, m. 11819° (iso-PrOH), picrate m. 215-16° (decomposition). IVa (5.3 g.) refluxed 1 h. with 60 mL. ethanolamine containing 0.5 g. Na and poured into H2O afforded 5 g. 2-anilino-4-(2-hydroxyethylamino)quinazoline (VI), m. 147-9° (PhMe); picrate, prisms, m. 185° (H2O). At 20°, the reaction yield was 5.15 g. VI was stable to alc. alkali and with HNO2 at 10° gave the nitrite, m. 163-5° (decomposition). 2-Chloro-4-(2-hydroxyethylamino)quinazoline (1 g.) and 0.42 g. PhNH2 in 10 mL. H2O refluxed 45 min. with 0.2 mL. HCl, yielded on basification 1.14 g. VI.

When you point to this article, it is believed that you are also very interested in this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Regioselective Tandem C-H Alkylation/Coupling Reaction of ortho-Iodophenylethylenes via C,C-Pallada(II)cycles, published in 2021-10-01, which mentions a compound: 111-24-0, Name is 1,5-Dibromopentane, Molecular C5H10Br2, Computed Properties of C5H10Br2.

Five-membered C,C-pallada(II)cycles are a unique class of diorganopalladium species with favorable stability and an electron-rich nature, leading to efficient sequential reactions with diverse electrophiles and nucleophiles. Specifically, the development of aryl-alkenyl-palladacycle-based transformations could provide an attractive approach with regio- and stereocontrol for the construction of multifunctionalized arylethylenes. However, currently, the C,C-pallada(II)cycle formation relies on a rigid skeleton or steric congestion in the backbone to promote cyclopalladation, and the formation of aryl-alkenyl-palladacycle without an α-substituent has not been achieved. Furthermore, reactions that could discriminate between the two sp2 carbon centers of such C(sp2),C(sp2)-palladacycle remain elusive. Herein, a regioselective three-component tandem alkylation/coupling reaction applicable for a variety of non-, α-, or β-substituted and α,β-disubstituted ortho-iodophenylethylenes is reported. Electron-rich 2-pyridone ligands are employed to enable the cyclopalladation process leading to aryl-alkenyl-palladacycle intermediates, of which the two C-Pd bonds are discriminated toward alkylation by their inherent steric and electronic differences. Good linear free-energy relationships between regio-/chemoselectivities and Hammett σ values are observed

When you point to this article, it is believed that you are also very interested in this compound(111-24-0)Computed Properties of C5H10Br2 and due to space limitations, I can only present the most important information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis