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Continued exploration of the SAR around the lead imidazopyridine histamine H3 antagonist 1 has led to the discovery of several related series of heterocyclic histamine H3 antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The regioselective silylation of C(sp3)-H bonds at the benzylic position in 4-alkylpyridines with hydrosilanes is described. The reaction proceeds in the presence of a catalytic amount of Ir4(CO)12 or Ir(acac)(CO)2, which possess CO as a ligand, or [Ir(OMe)(cod)]2 under 1 atm of CO. After optimizing the reaction conditions, by using other pyridine derivatives, such as 3,5-dimethylpyridine, as additives, the low product yields of 2-substituted 4-methylpyridines were improved markedly.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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In continuation of our work on excess thermodynamic properties of non-electrolyte solutions containing pyridine bases with n-alkanes, we have determined excess molar volumes VE for 2,4-ditnethylpyridine + C6 to C10 n-alkanes at 25C. For the investigated systems no VE values were available in the literature for compari1 son with our data. The experimental VE was used to test the Prigogine-Flory-Patterson theory (PFP), Extended Real Associated Solutions model (ERAS) and the Treszczanowicz-Benson method (TB).

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Adsorption of 16 organic compounds from the gas phase by 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl}benzaldehyde was studied by gas chromatography. It was shown by means of differential scanning calorimetry that 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl]benzaldehyde is an enantiotropic polymorphic mesogen and forms smectic and nematic liquid crystal phases. Electron-donor isomers of methylpyridine and dimethylpyridine, isomers of weakly polar xylenes and cresols, and enantiomers of 2,3-butanediol and terpene hydrocarbons, capable of various types of intermolecular interactions with mesogenic aldehyde, were selected as adsorbates. Specific retention volumes of adsorbates and criteria for their separation were calculated. The effect of temperature and chemical nature of the adsorbates on their adsorption redistribution in the gas?liquid crystal system is discussed. It was found experimentally that the adsorbent based on 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazeny}lbenzaldehyde exhibits high selectivity for close-boiling organic compounds of various nature and good efficiency and productivity in their separation.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Quantum chemical methods are particularly significant in the study of electrochemistry and provide researchers with a relatively quick way of studying the structure and behaviour of corrosion inhibitors. The originality of this review article is based on the fact that it is the first and unique general reference for all those interested in the use of quantum chemical methods in corrosion inhibitor studies. It begins with a concise summary of the most used quantum chemical parameters and methods and then summarizes the results of research articles in corrosion science over the past 20 years.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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The recyclization of N-alkyl-alpha-methylpyridinium salts with an N-alkyl chain consisting of 12 and 16 carbon atoms under the influence of aqueous solutions of sulfites of various amines was studied. It was established that the formation of micellar structures in aqueous solutions of these salts affects the direction of the reactions.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Our Top Choice Compound: C7H9N

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In this work the parameters of Low Temperature Conversion – LTC were applied in a centrifuged sludge from a sewage treatment plant located in Rio de Janeiro, Brazil. Before the conversion, the sludge was dried and analyzed by TGA to observe its behavior with increasing temperature. The chemical composition of the crude pyrolysis oil was analyzed by FTIR, 1H NMR and GC-MS. The results showed that the oil is a mixture of hydrocarbons, oxygenated and nitrogenated compounds. Using a catalytic treatment it was possible to fractionate the oil where the predominant constituents were hydrocarbons showing that the cracking was effective. An important result was the difference between the calorific value of dry sludge (10MJkg-1), the pyrolysis oil (36MJkg-1) and one of the fractions separated by catalytic cracking (40MJkg-1) when compared with commercial diesel (45MJkg-1).

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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A mild and efficient method for the oxidation of N-heteroaromatic compounds to the corresponding N-oxides using H2O2 in the presence of hexaphenyloxodiphosphnium triflate (Hendrickson reagent) in EtOH at room temperature was reported. This methodology presented relatively fast and selective reactions to afford the N-oxides in good yields. The reverse reactions, deoxygenation reactions, were also carried out under the same reaction conditions by KI to produce the tertiary amines.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Fifty-six ionic liquids were efficiently synthesized in parallel format under one-pot, solvent-free microwaveassisted synthesis. These compounds were evaluated as extracting agents of nitrogen-containing compounds from a real Diesel feed before being submitted to the hydrodesulfurization process to obtain ultralow sulfur Diesel. Our results showed that halogenated ionic liquids are an excellent alternative due to these ionic liquids are relatively inexpensive, presenting a high selectivity for the extraction of nitrogen-containing compounds and can be regenerated and recycled.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

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Lutidines react with Na/K alloy and diorganylaminodifluoroboranes in n-hexane.The products formed depend upon the position of the methyl groups.While from 3,4-lutidine (C) the bis(lutidinyl)aminoboranes 2-5 are obtained, the 2,4-, 2,5-, and 3,5-lutidines (F, G, H) give the 11a,11b-dihydro-<1,3,2>-diazoborolo-<5,1-b;3,4-b'>-dilutidines 11-17. 4-Picoline reacts analogously to give 10.Pyridine (A) and colidine (B) give adducts with borane.From 2,3-lutidine (D), the 1,4-dihydro-1,4-bis(fluoraminoboryl)-2,3-lutidine 8 is obtained. 1H, 11B, 13C, 19F, 29Si, 15N NMR and MS data are given.For 8 and 14 the X-ray structures are reported.Key Words: Pyridine, Picoline, Lutidine, Collidine, Dilutinylaminoboranes

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis