Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, and are directly involved in the manufacturing process of chemical products and materials. Synthetic Route of 126456-43-7
One ring to bring them all: 4,5-Spirocycles derived from 3-oxetanone and beta-heteroatom-substituted amino compounds undergo a Lewis acid mediated reaction cascade to form saturated nitrogen heterocycles. The unique reactivity of 3-oxetanone facilitates access to biologically important morpholines, piperazines, and thiomorpholines with an otherwise difficult-to-access substitution pattern from readily available starting materials. Copyright
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Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis