Month: April 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Biological evaluation and molecular docking of substituted quinazolinones as antimicrobial agents.Name: 2-Aminoquinazolin-4(3H)-one.

Antibiotic resistance in the community is a growing public health concern due to the continued emergence of multi drug resistant bacterial strains. In view of this fact, the design and synthesis of newer antibacterials are of immense significance and continue to attract the attention of numerous medicinal chemists. The aim of this study was to investigate the effect of four quinazolinone derivatives (Ia, II, III and IV) on the microbial cell morphol. and genes coded for rRNA subunits. It was extended also to elucidate the effect of the most active derivatives on DNA-gyrase enzyme by performing a mol. docking study. Quinazolinone derivatives revealed good anti-bacterial activities, especially against Gram-pos. strains through their interaction with cell wall and DNA structures. The tested compounds showed moderate activity against fungal strains through affecting the internal structures of fungal cell in addition to studied genes. Compound II was found to be the most active gyrase inhibitor as illustrated by the docking study. Conclusion: The type and position of chem. substituents confer the antimicrobial activity of quinazolinone.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ) is researched.Safety of 5-(4-Pyridyl)-1H-tetrazole.Sha, Jing-Quan; Sun, Jing-Wen; Wang, Cheng; Li, Guang-Ming; Yan, Peng-Fei; Li, Meng-Ting; Liu, Ming-Yuan published the article 《Syntheses of POM-templated MOFs containing the isomeric pyridyltetrazole》 about this compound( cas:14389-12-9 ) in CrystEngComm. Keywords: silver pyridyltetrazole polyoxometalate template MOF hydrothermal preparation crystal structure; luminescence silver pyridyltetrazole polyoxometalate template MOF. Let’s learn more about this compound (cas:14389-12-9).

By introducing the isomeric pyridyltetrazole into POMs, four POM-templated MOFs compounds, H[Ag6(2-pytz)4(H2O)4][PW12O40]·6H2O (1), [Ag3(3-pytz)2]2[AgPW12O40] (2), H[KAg7(4-pytz)5][SiW12O40] (3), {H[NaAg7(4-pytz)5(H2O)0.5][GeMo12O40]}2 (4) [pytz = 5-(pyridyl) tetrazolate], were hydrothermally synthesized and characterized by routine methods and single-crystal x-ray crystallog. Due to 2-pytz as a bridging linker and chelator, compound 1 displays a 2D MOF with a void (∼19.1 × 8.8 Å), in which the Keggin anions as sandwich templates locate in the adjacent two voids. In 2, 3-pytz as a shorter radiating linker generates a compacted 2D MOF, in which the Keggin anions as chain templates direct the formation of a stair-like MOF. In the isostructural compounds 3 and 4, 4-pytz as the bridging and radiating linkers form 3D covalent MOFs with larger voids (∼25.3 × 12.5 Å), in which the Keggin anions as double-templates occupy the voids in a “”shoulder-to-shoulder”” mode. In addition, the photoluminescence of the compounds were studied.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Formula: C5H10Br2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents. Author is Satyanarayana, Mavurapu; Shukla, Poonam; Tripathi, Brajendra K.; Tiwari, Priti; Srivastava, Arvind K.; Pratap, Ram.

A series of chalcone and flavone derivatives I [R1 = 4-MeOC6H4, 1,3-benzodioxol-5-yl; n = 2, 3] II [R = 3,5-di-OCH2Ph, 3,4-di-OCH2Ph, 3,4,5-tri-MeO, 3,4-di-MeO, 3,5-di-MeO; n = 1, 2] based on 2,4-thiazolidinedione had been synthesized and evaluated for in vivo antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also for antidyslipidemic activity in the triton model. Compounds II [R = 3,4,5-tri-MeO, 3,4-di-MeO, 3,5-di-MeO; n = 2] exhibited potent blood glucose-lowering activity in both SLM and STZ models. Compounds I [R1 = 1,3-benzodioxol-5-yl; n = 3], and II [R = 3,4,5-tri-MeO, 3,4-di-MeO, 3,5-di-MeO; n = 1, 2] showed moderate lipid-lowering activity. The selected most potent compounds I [R1 = 1,3-benzodioxol-5-yl; n = 3] and II [R = 3,4,5-tri-MeO; n = 2] were also studied in db/db mice for both antihyperglycemic and antidyslipidemic activity.

Here is just a brief introduction to this compound(111-24-0)Formula: C5H10Br2, more information about the compound(1,5-Dibromopentane) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 14389-12-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about A solid-state density functional theory investigation of the effect of metal substitution (Metal = Mn, Cd, Co) on the terahertz spectra of isomorphous molecular metal 5-(4-pyridyl)tetrazolato complexes. Author is Pellizzeri, Steven; Witko, Ewelina M.; Korter, Timothy M.; Zubieta, Jon.

The crystal structure and exptl. terahertz spectroscopy of an isomorphous series [Mn(C6H4N5)2(H2O)4]·2H2O (Mn-4PT), [Co(C6H4N5)2(H2O)4]·2H2O (Co-4PT), and [Cd(C6H4N5)2(H2O)4]·2H2O (Cd-4PT) were compared using solid-state d. functional theory (DFT) simulations. The effect of the central metal atom was studied to determine the influence on the low energy lattice and mol. vibrations exhibited at 10-100 cm-1, known as the terahertz (THz) region. Using solid-state DFT the normal modes of these THz vibrations were determined and the mass and size of the metal center has a large effect in this region. Each complex exhibited common vibrational modes involving whole ligand motion around the central metal atom. These vibrations shift to lower frequencies with a drastic mass increase; however, this trend is reversed with the smaller mass change between the Mn and Co due to the stronger Co-N bond compared to the Mn-N bond.

Here is just a brief introduction to this compound(14389-12-9)Product Details of 14389-12-9, more information about the compound(5-(4-Pyridyl)-1H-tetrazole) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Terao, Yoshito; Nomoto, Michiyo; Satoh, Tetsuya; Miura, Masahiro; Nomura, Masakatsu published the article 《Palladium-catalyzed dehydroarylation of triarylmethanols and their coupling with unsaturated compounds accompanied by C-C bond cleavage》. Keywords: triarylmethanol dehydroarylation palladium phosphine; diaryl ketone preparation; arene preparation; alkyne triarylmethanol dehydroarylation hydroarylation palladium phosphine; arylalkenes stereoselective preparation; palladium phosphine dehydroarylation catalyst.They researched the compound: Tri(naphthalen-1-yl)phosphine( cas:3411-48-1 ).Category: chiral-nitrogen-ligands. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3411-48-1) here.

Triarylmethanols were effectively dehydroarylated and reacted with some unsaturated compounds by using an appropriate palladium catalyst system such as Pd(OAc)2-P(1-Nap)3 to give the corresponding arenes and hydroarylation products, e.g., I, resp., along with diaryl ketones.

Here is just a brief introduction to this compound(3411-48-1)Category: chiral-nitrogen-ligands, more information about the compound(Tri(naphthalen-1-yl)phosphine) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Wang, Xiu-Li; Li, Tian-Jiao; Tian, Ai-Xiang; Li, Na; Yang, Yang; Ning, Ya-Li; Hou, Xue published the article 《Influence of N-donor sites in 5-(x-pyridyl)-1H-tetrazole ligands (x = 2, 4) on assembly of polyoxometalate-based compounds modified by multinuclear metal clusters and infinite chains》. Keywords: copper silver pyridyltetrazolate molybdophosphate molybdosilicate preparation structure electrochem photocatalyst; crystal structure copper silver pyridyltetrazolate molybdophosphate molybdosilicate polyoxometalate.They researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).Recommanded Product: 14389-12-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:14389-12-9) here.

Through tuning the N-donor site of the pyridyl group in 5-(x-pyridyl)-1H-tetrazole ligands (x = 2, 4), four new Keggin-based compounds, [Cu7(2-ptz)8(OH)2(H2O)2(HPMoVI10MoV2O40)]·4H2O (1), [Cu5(2-ptz)6(HPMoVI10MoV2O40)(H2O)4]·4H2O (2), [Ag6(4-ptz)4(H2SiMo12O40)] (3) and [Ag5(4-ptz)4(H2PMo12O40)]·5H2O (4) (2-ptzH = 5-(2-pyridyl)-1H-tetrazole, 4-ptzH = 5-(4-pyridyl)-1H-tetrazole), were successfully synthesized under hydrothermal conditions and structurally characterized. Compound 1 possesses two kinds of CuII subunits: penta-nuclear clusters and mono-nuclear subunits, which connect with each other to form a one dimensional (1D) stair-like metal-organic chain. The adjacent 1D stair-like chains are further linked by tetradentate Keggin anions to construct a 2D layer. In compound 2, the tetra-nuclear CuII clusters and mono-nuclear CuII subunits construct a 2D metal-organic layer, which is further linked by bidentate Keggin anions to build a 3D framework. In compound 3, the 4-ptz ligand links AgI ions with tetrazole groups to form 1D infinite Ag-ptz chains, which are extended by the pyridyl group of 4-ptz and the tetrazole groups of other 4-ptz mols. to construct a 2D layer. The adjacent 2D layers are further linked by 6-connected Keggin anions to build a 3D framework. In compound 4, the 4-ptz ligands are linked by AgI ions to form 1D infinite Ag-ptz belts. The Keggin anions are linked by AgI ions to construct another infinite inorganic chain, in which each Keggin anion provides six oxygen atoms to coordinate with the AgI ions from adjacent Ag-ptz belts to construct a 2D layer. The roles of the ptz ligands with different N-donor sites in the construction of multinuclear clusters and 1D chains are discussed. The electrochem. and photocatalytic properties of the title compounds were investigated as well.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C30H21P. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Naphthyne: Osmium and Ruthenium Cluster Derivatives.

Reaction of the 1-naphthyl derivatives E(1-C10H7)3 (E = P, As) with M3(CO)12 (M = Ru, Os) affords naphthyne complexes M3(CO)8(μ-H)2[μ3-η4-(C10H7)2E(C10H5)] (shown as I; M = Os, Ru; E = As, P; R = 1-naphthyl 5-8) in moderate to good yield, via double metalation of the unsubstituted aromatic ring. Metalation of the substituted aromatic ring results in one complex, Os3(CO)9(μ-H)[(C10H7)2P(C10H6)]. Cleavage of an As-naphthyl bond affords a low yield of the naphthyne complex Ru4(CO)10(μ-CO)[μ4-As(C10H7)][μ4-C10H6] (11), in which the aryne ring is at an angle of 75° to the Ru4 plane and acts as a four-electron donor, making 11 formally electron deficient. Crystals of 5 are monoclinic, with a 25.746(1), b 9.688(2), c 33.521(1) Å, β 108.647(3)°, Z = 8, and space group C2/c. Those of 11 are triclinic, with a 11.433(3), b 14.746(2), c 9.958(1) Å, α 96.81(1), β 102.34(2), γ 78.69(2)°, Z = 2, space group P1̅. The structures were solved by the Patterson method and were refined by full-matrix least-squares procedures to R = 0.033 and 0.030 (Rw = 0.031 and 0.028) for 5308 and 4933 reflections with I ≥ 3σ(I), resp.

Here is just a brief introduction to this compound(3411-48-1)Computed Properties of C30H21P, more information about the compound(Tri(naphthalen-1-yl)phosphine) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Related Products of 20198-19-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Synthesis of 2-amino-4-quinazolones and spectral study of their tautomeric equilibrium state. Author is Shakhidoyatov, Kh. M.; Yun, L. M.; Samiev, R. A..

The identity of UV spectra of the parent and methylated aminoquinazolones I (R,R1 = H,H; Me,H; H,Me; Me,Me) was evidence for a single amino-keto tautomeric form with double bond C4:O and N1:C2. Comparison of UV spectra in neutral and basic media established that deprotonation occurs at N3 only in the parent (R,R1 = H,H) compound, consistent with the observed methylation at N3; i.e., no deprotonation of the amino group is observed under these conditions.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 111-24-0, is researched, SMILESS is BrCCCCCBr, Molecular C5H10Br2Journal, Indian Journal of Heterocyclic Chemistry called Microwave-assisted synthesis of quinazolines linked with 1,8-naphthalimide, chromene derivatives and their antimicrobial activity, Author is Ashok, D.; Ramakrishna, Katta; Nagaraju, Nalaparaju; Dharavath, Ravinder; Reddy, M. Ram; Sarasija, M., the main research direction is quinazoline preparation antibacterial antifungal green chem microwave.SDS of cas: 111-24-0.

The synthesis of several quinazolines containing 1,8-naphthalimide and chromene moieties under conventional and microwave irradiation methods has been reported. The microwave irradiation gave higher yields, shorter reaction time as compared to conventional heating method using green solvents, eco-friendly reaction conditions. Furthermore, the titled compounds were screened for their in vitro antimicrobial activity against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, and Escherichia coli as well as fungi such as Aspergillus niger, Aspergillus flavus, and Fusarium oxysporum. Compounds exhibited promising antimicrobial activity.

Here is just a brief introduction to this compound(111-24-0)SDS of cas: 111-24-0, more information about the compound(1,5-Dibromopentane) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ) is researched.Synthetic Route of C8H7N3O.Masharipov, S.; Nazhimov, K. O.; Kasymova, S. S.; Askarov, M. A. published the article 《4-Quinazolone derivatives as stabilizers for PVC》 about this compound( cas:20198-19-0 ) in Plasticheskie Massy. Keywords: quinazolone derivative heat stabilizer PVC. Let’s learn more about this compound (cas:20198-19-0).

Derivatives of 4-quinazolone increased the thermal stability of PVC by 2-16 fold. The inhibiting action of 4-quinazolone derivatives during PVC degradation is due to to the binding of gaseous HCl and replacement of labile Cl atoms by the quinazolone groups, and their stabilization activity depends on the type of groups replacing H in 4-quinazolone. The thermal stability of PVC linoleum containing 2-amino-4-quinazolone-Co acetate complex was 2.5-3 fold higher than that of PVC containing com. Ca stearate, without changes in physicomech. properties and with improvement of properties in some cases.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis