Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Polymerization of functionalized norbornenes: Trends and reactivity ratios, published in 2003, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, Application In Synthesis of Tri(naphthalen-1-yl)phosphine.

The polymerization of functionalized norbornenes by the known Pd(II) polymerization catalyst, R3P-(1,5-cyclooctadiene)Pd(Me)Cl, was examined Steric and electronic effects of various phosphine ligands on the polymerization activity were examined in relation to the norbornene monomers 5-butyl-2-norbornene (Butyl-NB), 5-Et ester-2-norbornene (EtEster-NB) and 5-methylacetate-2-norbornene (MeOAc-NB) and their exo/ endo preference. In all the polymerizations, the exo isomer was preferentially polymerized The Butyl-NB homopolymerization rate was fastest for sterically bulky phosphines while the EtEster-NB and MeOAc-NB homopolymerization rates were fastest for weakly basic triarylphosphines. The rate of polymerization in the copolymerizations of Butyl-NB and EtEster-NB or MeOAc-NB was faster with weakly basic triarylphosphines. Polymerizations with MeOAc-NB were slower than comparable polymerizations with EtEster-NB due to more facile coordination of the carbonyl functionality. This was confirmed by comparing the rate of Butyl-NB polymerization in the copolymerizations and in the presence of the corresponding norbornane. Reactivity ratios the various catalysts were calculated by the sum-of-squares space method.

I hope my short article helps more people learn about this compound(Tri(naphthalen-1-yl)phosphine)Application In Synthesis of Tri(naphthalen-1-yl)phosphine. Apart from the compound(3411-48-1), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Heat stabilizers for poly(vinyl chloride) based on 4-quinazolinone derivatives.Recommanded Product: 2-Aminoquinazolin-4(3H)-one.

The thermooxidative stability of PVC was increased 2-16 folds by addition of 4-quinazolinone (I) derivatives due to the bonding of HCl and substituting the quinazolinone group for the labile Cl group. The stabilizing activity of I derivatives under isothermal and nonisothermal conditions depended on the nature of groups substituting the H atom in I. Mixtures of 2-amino-4-quinazolinone Co and Na salts with Ca stearate and Pb silicate stabilizers had a synergistic effect on the thermooxidative stability of PVC. The Co acetate complex of 2-amino-4-quinazolinone increased the thermal stability of PVC linoleum 2.5-3 folds compared to conventional stabilizer (Ca stearate) without adversely affecting the physicomech. properties of the linoleum.

I hope my short article helps more people learn about this compound(2-Aminoquinazolin-4(3H)-one)Recommanded Product: 2-Aminoquinazolin-4(3H)-one. Apart from the compound(20198-19-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Molecules called Design, synthesis, and antitumor activity of a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones, Author is Xing, Naiguo; Chen, Chen; Zhong, Qiu; Zheng, Shilong; Wang, Guangdi; He, Ling, which mentions a compound: 6684-39-5, SMILESS is ClC1=NC=C(C=C1)[S](=O)(=O)Cl, Molecular C5H3Cl2NO2S, Recommanded Product: 2-Chloro-5-pyridinesulfonyl chloride.

Based on benzenesulfonylazaspirodienone (HL-X9) identified in the previous work, the lead compound for better efficacy is optimized, thereby synthesizing a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-one derivatives such as I through a key step of metal-catalyzed cascade cyclization. The preliminary antiproliferative tests have shown that the anticancer activities of acetyl-protected mannose-linked sulfonylazaspirodienone derivatives have been greatly improved. Among them, II is the most potent derivative, with IC50 values of 0.17μM, 0.05μM, and 0.07μM for A549, MDA-MB-231, and HeLa cell lines, resp. Flow cytometry anal. shows that II arrests MDA-MB-231 cells in the G2/M phase and has a certain effect on the apoptosis of MDA-MB-231 cells. In addition, the acute toxicity of II was lower than that of adriamycin.

I hope my short article helps more people learn about this compound(2-Chloro-5-pyridinesulfonyl chloride)Recommanded Product: 2-Chloro-5-pyridinesulfonyl chloride. Apart from the compound(6684-39-5), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 2-Chloro-5-pyridinesulfonyl chloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloro-5-pyridinesulfonyl chloride, is researched, Molecular C5H3Cl2NO2S, CAS is 6684-39-5, about Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 3. Structure-Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N’-arylpiperazine Series. Author is Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St. Jean, David J..

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small mol. to its endogenous inhibitor, glucokinase regulatory protein (GKRP). These initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (I, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound I bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives II and III possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

I hope my short article helps more people learn about this compound(2-Chloro-5-pyridinesulfonyl chloride)Safety of 2-Chloro-5-pyridinesulfonyl chloride. Apart from the compound(6684-39-5), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Category: chiral-nitrogen-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about One- and two-dimensional coordination polymers of substituted tetrazoles with cadmium(II). Author is Darling, Kari; Ouellette, Wayne; Pellizzeri, Steven; Smith, Tiffany; Vargas, Jose; Tomaszfski, Steven; O’Connor, Charles J.; Zubieta, Jon.

The reactions of Cd(NO3)2·4H2O with derivatized tetrazolate ligands yielded coordination polymers of the Cd(II)/iminetetrazolate/anion/solvent family. [Cd(4-Hpyrtet)2(OH)2] (1) (4-Hpyrtet = 4-pyridinetetrazole) is two-dimensional with the ligand in the protonated form with the tetrazole N3 site as the protonation location. The Co(II) and Cu(II) analogous [M(4-pyrtet)2(H2O)2] (M = Co (2), Cu (3)) are structurally similar to 1, but with the aqua ligands projecting to the intralamellar voids rather than into the interlamellar domains, as observed for the hydroxy groups of 1. The 2-pyridyltetrazolate derivative [CdCl(2-pyrtet)(DMF)] (4) is 1-dimensional with chloride and DMF ligands projecting from a {Cd(2-pyrtet)}nn+ ribbon. Compound 5, [Cd4Cl6(prytet)2(DMF)4], (prytet = pyrazinetetrazolate) is two-dimensional and exhibits {Cd4Cl6} secondary building units linked through tetrazolate groups and pyrazine units into the network structure. The azide derivative, [Cd3(N3)4(4-pyrtet)2(H2O)2] (6), is a pillared layer three-dimensional framework with {Cd3(N3)4(tetrazolate)2(H2O)2}n layers through the 4-pyrtet ligands.

I hope my short article helps more people learn about this compound(5-(4-Pyridyl)-1H-tetrazole)Category: chiral-nitrogen-ligands. Apart from the compound(14389-12-9), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yun, L. M.; Babadzhanova, S. B.; Kadyrov, Ch. Sh.; Shakhidoyatov, Kh. M. researched the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ).Application In Synthesis of 2-Aminoquinazolin-4(3H)-one.They published the article 《Amidomethylation of quinazoline derivatives by N-methylolphthalimide and -pyrolidinone》 about this compound( cas:20198-19-0 ) in Doklady Akademii Nauk UzSSR. Keywords: quinazolinone amidomethylation; alkylation quinazolinone. We’ll tell you more about this compound (cas:20198-19-0).

Alkylation of 2-amino-4-quinazolinone (I) or its 3-Me derivative with N-(hydroxymethyl)pyrrolidone or -phthalimide took place as expected to give the N-amidomethyl derivatives II and III (R = H, Me). III (R = H) on reaction with N2H4 gave I, HCHO, and NH3. With 4-quinazolinone the alkylation failed; only products of further reaction were isolated.

I hope my short article helps more people learn about this compound(2-Aminoquinazolin-4(3H)-one)Application In Synthesis of 2-Aminoquinazolin-4(3H)-one. Apart from the compound(20198-19-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Journal fuer Praktische Chemie (Leipzig) called The nitrile-carboxamide rearrangement and the formation of heterocycles from 2-cyanocyclohexenylurea, Author is Bischoff, Christian; Schroeder, Edith, the main research direction is nitrile carboxamide rearrangement; cyanocyclohexenylurea cyclization transamination amine; cyclohexenylurea cyano reaction amine; urea cyanocyclohexenyl reaction amine.Formula: C8H7N3O.

2-H2NC6H4CONH2 reacted with BrCN to give 85% 2-NCC6H4NHCONH2 via a nitrile-carboxamide rearrangement. Cyclohexenylurea I (R = R1 = H) reacted with amines to give 35-100% cyclization products II (R2 = 4-ClC6H4, 2,4,5-Cl3C6H2, Ph, PhCH2, 1-naphthyl, 4-O2NC6H4, H), with amines to give 29-86% transamination products I [NRR1 = NHCHMe2, NH(CH2)5CO2H, morpholino, piperidino], and with α-amino acids to give 32-49% cyclization products III (R3 = H, Pr). 2-Oxocyclohexanecarboxamide reacted with 2-aminobenzimidazole to give 100% benzimidazoquinazolinone IV.

I hope my short article helps more people learn about this compound(2-Aminoquinazolin-4(3H)-one)Formula: C8H7N3O. Apart from the compound(20198-19-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A Crystalline Iron Terminal Methylidene, published in 2021-10-20, which mentions a compound: 1663-45-2, mainly applied to crystalline iron terminal methylidene, Quality Control of 1,2-Bis(diphenylphosphino)ethane.

Iron methylidene species are alleged intermediates in the Fischer-Tropsch process and in olefin cyclopropanation, yet iron methylidene complexes with unambiguously established mol. and electronic structures remain elusive. In this study, we characterize an iron terminal methylidene complex by single-crystal X-ray diffractometry (scXRD), CHN combustion elemental anal., 1H/13C/31P/1H-13C NMR, and zero-field 57Fe Mössbauer spectroscopy and study its reactivity. A series of closely related complexes in different oxidation states were synthesized, isolated and characterized in order to validate the electronic structure of the title methylidene complex. The computational anal. substantiates the proposed Fischer-type electronic description while emphasizing high Fe=CH2 bond covalency, considerable double bond order, and thus, substantial alkylidene character.

I hope my short article helps more people learn about this compound(1,2-Bis(diphenylphosphino)ethane)Quality Control of 1,2-Bis(diphenylphosphino)ethane. Apart from the compound(1663-45-2), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-Catalyzed Silacyclization of (Hetero)Arenes with a Tetrasilane Reagent through Twofold C-H Activation. Author is Wang, Dingyi; Li, Mingjie; Chen, Xiangyang; Wang, Minyan; Liang, Yong; Zhao, Yue; Houk, Kendall N.; Shi, Zhuangzhi.

The use of an operationally convenient and stable silicon reagent (octamethyl-1,4-dioxacyclohexasilane, ODCS) for the selective silacyclization of (hetero)arenes via twofold C-H activation is reported, giving oxadisilole-annelated indole, carbazoles and arene phosphine derivatives This method is compatible with N-containing heteroarenes such as indoles and carbazoles of varying complexity. The ODCS reagent can also be utilized for silacyclization of other types of substrates, including tertiary phosphines and aryl halides. A series of mechanistic experiments and d. functional theory (DFT) calculations were used to investigate the preferred pathway for this twofold C-H activation process.

I hope my short article helps more people learn about this compound(Tri(naphthalen-1-yl)phosphine)Computed Properties of C30H21P. Apart from the compound(3411-48-1), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Formula: C5H10Br2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about N-spirocyclic ammonium-functionalized graphene oxide-based anion exchange membrane for fuel cells. Author is Long, Chuan; Lu, Chuanrui; Li, Yunxi; Wang, Zhihua; Zhu, Hong.

Graphene oxide (GO) is a potential material in the electrode and membrane of polymer electrolyte membrane fuel cells due to its unique structure and various oxygen-containing functional groups. A class of three-layered GO/poly(phenylene oxide) for AEMs was prepared in this work. GO was functionalized with highly stable 6-azonia-spiro [5.5]undecane groups and used as a fast hydroxide conductor, named ASU-GO. Functionalized by N-spirocyclic cations, poly (phenylene oxide) (PIPPO) was then combined with ASU-GO and GO to fabricate the ASU-GO/PIPPO and GO/PIPPO. Notably, the maximum hydroxide conductivity of the ASU-GO/PIPPO was 73.7 mS cm-1 at 80 °C, which was 3 times higher than that of the GO/PIPPO. The enhancement in hydroxide conductivity was due to the changes in the hydroxide transport mechanism and the poor stacked structure of the ASU-GO layer. Only 10.8% drops in hydroxide conductivity of ASU-GP/PIPPO after the alk. test (1 M KOH at 80 °C for 700 h). Furthermore, the ASU-GO/PIPPO-50 membrane showed a maximum peak power d. of 102 mW cm-2, demonstrating the prepared membrane was promising in the AEM applications.

I hope my short article helps more people learn about this compound(1,5-Dibromopentane)Formula: C5H10Br2. Apart from the compound(111-24-0), you can read my other articles to know other related compounds.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis