Month: April 2022

HPLC of Formula: 1663-45-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about Inclusion of bidentate phosphine molecules in the supercage of FAU zeolite. Author is Okumura, Kazu; Morita, Sachiko; Ohtsuki, Akimichi; Takaba, Hiromitsu.

Bidentate phosphines (Ph2P(CH2)nPPh2) with different alkyl chain lengths (n = 1-10) were included in the supercage (SC) of FAU-zeolite. Thermal treatment of the mixture of a bidentate phosphines and FAU-zeolite at 443 K resulted in the inclusion of the former into the SC, with ≤ 0.75 mols. per SC. The included mols. were strongly bound by FAU-zeolite, with desorption observed at higher temperatures compared to those of unloaded ones. The sp. surface area of the FAU-zeolite decreased linearly with an increase in the number of phosphines included. This tendency was more emphasized in phosphines with n = 6-10 compared with those with n = 1-5. A characteristic shift in the C-C stretching band of the benzene ring was observed in the Fourier-transform IR spectroscopy (FT-IR) spectrum, due to the strong interaction between bidentate phosphines and FAU-zeolite; the extent was more when using *BEA-loaded ones. Formation of the inclusion compounds between bidentate phosphines and FAU zeolites was observed with the mol. dynamics (MD) calculations The bidentate phosphines included in the SC of the FAU-zeolite were reacted with PdCl2 to form Pd complexes. The detailed anal. of the Pd complexes with Pd K-edge EXAFS revealed a characteristic decrease in the Pd-Cl bond distance with the use of complexes with n = 3 and 4, suggesting that the local structure around Pd was distorted through the interaction of the Pd complexes with the pores of the FAU-zeolite. The Pd complexes included in the SC were active for allylic alkylation between allyl Me carbonate and Et acetoacetate.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Choi, Byeong-Min; Son, Seok-Hwan; Lee, Chul-Wee; Park, Sun-Yeong; Chung, Min-Chul published the article 《Characterization and synthesis of molybdenum metal precursors for hydrocracking reaction of vacuum residues》. Keywords: molybdenum metal hydrocracking reaction.They researched the compound: 1,2-Bis(diphenylphosphino)ethane( cas:1663-45-2 ).HPLC of Formula: 1663-45-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1663-45-2) here.

In this study, Molybdenum precursors were synthesized with Triphenylphosphine, 1,2-Bis(diphenylphosphino)ethane, Pyridine, 2,2-Bipyricine as a ligands. The molybdenum precursors was used for Hydrocraking reaction of Vacuum Residue (VR). Hydrocracking reactions were carried out under the 430 °C and H2 pressure of 80 bar in an 100 mL high pressure reactor. New Molybdenum precursors were tested and their activities were compared with Mo-octoate. The Molybdeum-Phosphine precursor showed the best performances, high yield and low coke contents (below 0,5 wt%), in of hydrocracking for VR. To characterize the physicochem. properties of Moprecursor catalyst, various characterization techniques (NMR, XPS) were carried out. We confirmed that cokes in the reactor were contained the P atoms derived from ligand of Mo-precursor after hydrocracking of VR.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 14389-12-9, is researched, Molecular C6H5N5, about Solvent-dependent luminescent Cu(I) framework based on 5-(4-pyridyl)tetrazole, the main research direction is crystal structure copper pyridyltetrazole coordination polymer; copper pyridyltetrazole coordination polymer ethanol solvate preparation; luminescence copper pyridyltetrazole coordination polymer solvent dependent; solvent copper pyridyltetrazole coordination polymer fluorescence; framework polymer copper pyridyltetrazole nitrogen surface adsorption pore size.Computed Properties of C6H5N5.

A new Cu(I) coordination compound, Cu4(L)4·2EtOH (1), has been obtained from the solvothermal reaction of CuBr, 5-(4-pyridyl) tetrazole (HL), EtOH and NH3·H2O. The structure determination revealed that 1 has a 2D network, where each Cu(I) atom adopts a trigonal coordination mode. The 2D networks stacked in an ABAB sequence through the π-π interaction to form a 3D supramol. framework, giving a 1D channel along the b-axis. The TGA and powder XRD measurements revealed that the framework is stable after removal of the guest mols. Gas (N2) adsorption measurement was carried out for the framework and showed that N2 mols. cannot diffuse into the micropore and that only surface adsorption occurred. The photoluminescent study showed that compound 1 displays an interesting solvent-dependent luminescence.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Synthetic Route of C26H24P2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,2-Bis(diphenylphosphino)ethane, is researched, Molecular C26H24P2, CAS is 1663-45-2, about The Trityl-Cation Mediated Phosphine Oxides Reduction. Author is Laye, Claire; Lusseau, Jonathan; Robert, Frederic; Landais, Yannick.

Reduction of phosphine oxides into the corresponding phosphines using PhSiH3 as a reducing agent and Ph3C+[B(C6F5)4]- as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Polyhedron called Zeolite and sulfated zirconia as catalysts for the synthesis of 5-substituted 1H-tetrazoles via [2+3] cycloaddition of nitriles and sodium azide, Author is Teimouri, Abbas; Chermahini, Alireza Najafi, the main research direction is nitrile sodium azide cycloaddition zeolite sulfated zirconia catalyst; tetrazole green preparation.Category: chiral-nitrogen-ligands.

The [2+3] cycloaddition between various nitriles and sodium azide proceeded smoothly in the presence of zeolite and sulfated zirconia as effective catalysts, in water and DMF/MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeded through the in situ formation of catalyst azide species, followed by a successive [2+3] cycloaddition with the nitriles. This method has the advantages of high yields, simple methodol. and easy work-up. The catalyst can be recovered by simple filtration and reused with good yields.

There are many compounds similar to this compound(14389-12-9)Category: chiral-nitrogen-ligands. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Formula: C6H5N5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Ferromagnetic interaction and slow magnetic relaxation in a Co3 cluster-based three-dimensional framework. Author is Wu, Bing-Yan; Yang, Chen-I.; Nakano, Motohiro; Lee, Gene-Hsiang.

A Co3 cluster-based 3D framework, [Co3(4-ptz)4(N3)2(H2O)2].4DMF (I; 4-Hptz = 4-(1H-tetrazol-5-yl)pyridine), was prepared and its crystal and mol. structure was determined Crystal data: orthorhombic, Pnnm, a = 12.2143(13), b = 13.8051(15), c = 16.5293(17) Å, Z = 2, 2257 independent reflections, 176 refined parameters, R1 = 10390.0, wR2 = 0.2530 [I > 2σ(I)]. Compound I exhibits ferromagnetic interactions and slow-magnetic relaxation behavior.

There are many compounds similar to this compound(14389-12-9)Formula: C6H5N5. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Magyar Kemiai Folyoirat called Alkylation, transalkylation, and dealkylation of 2-amino-4-quinazolinols with amines and ammonia, Author is Lempert, Karoly; Breuer, Judit, which mentions a compound: 20198-19-0, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3O, Application In Synthesis of 2-Aminoquinazolin-4(3H)-one.

2-Mercapto-4-quinazolinol (1 g.) dissolved in a mixture of 10 mL. EtOH, 5 mL. H2O, and 0.33 g. KOH was treated with 0.38 mL. MeI at room temperature to yield 56.2% 2-methylthio-4-quinazolinol (I), m. 210-13°. Refluxing 1.35 g. I with 3 mL. morpholine, 1.05 mL. AcOH, and 15 mL. BuOH 45 h. gave 75% 2-morpholino-4-quinazolinol (II), m. 236-8° (BuOH). The 2-benzylamino-(III), 2-butylamino (IV), 2-amino (V) (40 h. at 120° in a sealed tube), 2-diethylaminoethylamino, and 2-anilino (VI) analogs were prepared similarly. Heating a mixture of 0.1 g. V, 1.5 mL. BuNH2, 0.42 mL. AcOH, and 10 mL. BuOH in a sealed tube at 140° 100 h. and steam distilling the product gave 40% IV, m. 184-6°. Heating a mixture of 0.7 g. III, 0.39 g. AcONH4, and 10 mL. absolute EtOH containing 0.2 g. NH3 at 140° in a sealed tube 120 h. gave 62.5% V, m. 306-8° (4:1 EtOH-HCONMe2). A mixture of 0.5 g. II, 0.33 mL. AcOH, 1.03 mL. BuNH2, and 10 mL. BuOH heated at 140° in a sealed tube 100 h. and the residue steam distilled gave 84% IV. A mixture of 0.62 g. VI, 1.43 mL. PhCH2NH2, 0.35 mL. AcOH, and 10 mL. BuOH was refluxed 90 h. and steam distilled to yield 61% III.

There are many compounds similar to this compound(20198-19-0)Application In Synthesis of 2-Aminoquinazolin-4(3H)-one. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis, published in 2019-08-08, which mentions a compound: 6684-39-5, Name is 2-Chloro-5-pyridinesulfonyl chloride, Molecular C5H3Cl2NO2S, Electric Literature of C5H3Cl2NO2S.

Osteoporosis is predominantly treated with drugs that inhibit further bone resorption due to estrogen deficiency. Yet, osteoporosis drugs that not only inhibit bone resorption but also stimulate bone formation, such as potentially inhibitors of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), may be more efficacious in the treatment of osteoporosis. Blockade of 17β-HSD2 is thought to increase intracellular estradiol and testosterone in bone, thereby inhibiting bone resorption by osteoclasts and stimulating bone formation by osteoblasts, resp. We here describe the design, synthesis, and biol. characterization of a novel bicyclic-substituted hydroxyphenylmethanone 17β-HSD2 inhibitor (I). Compound I is a nanomolar potent inhibitor of human 17β-HSD2 (IC50 of 6.1 nM) and rodent 17β-HSD2 with low in vitro cellular toxicity, devoid of detectable estrogen receptor α affinity, displays high aqueous solubility and in vitro metabolic stability, and has an excellent oral pharmacokinetic profile for testing in a rat osteoporosis model. Administration of I in a rat osteoporosis model demonstrates its bone-sparing efficacy.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mackman, Richard L.; Mish, Michael; Chin, Gregory; Perry, Jason K.; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G.; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E.; Fletcher, Simon P. researched the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ).Name: 2-Aminoquinazolin-4(3H)-one.They published the article 《Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B》 about this compound( cas:20198-19-0 ) in Journal of Medicinal Chemistry. Keywords: CHB TLR8 agonist optimization binding HBV DNA RNA. We’ll tell you more about this compound (cas:20198-19-0).

Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with a dysfunctional immune response, and therefore a selective TLR8 agonist may be an effective treatment option. Structure-based optimization of a dual TLR7/8 agonist led to the identification of the selective TLR8 clin. candidate (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol (GS-9688, (R)-7)(I). Potent TLR8 agonism (IL-12p40 EC50 = 220 nM) and >100-fold TLR7 selectivity (IFN-α EC50 > 50μM) was observed in human peripheral blood mononuclear cells (PBMCs). The TLR8-ectodomain:(R)-7 complex confirmed TLR8 binding and a direct ligand interaction with TLR8 residue Asp545. Oral (R)-7 had good absorption and high first pass clearance in preclin. species. A reduction in viral markers was observed in HBV-infected primary human hepatocytes treated with media from PBMCs stimulated with (R)-7, supporting the clin. development of (R)-7 for the treatment of CHB.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Ether spaced N-spirocyclic quaternary ammonium functionalized crosslinked polysulfone for high alkaline stable anion exchange membranes, published in 2020-03-15, which mentions a compound: 111-24-0, mainly applied to ether spirocyclic quaternary ammonium crosslinked polysulfone anion exchange membrane, Category: chiral-nitrogen-ligands.

N-spirocyclic cations containing anion exchange membranes (AEMs) possess excellent alk. stability, but poor mech. and conductive properties due to the rigid N-spirocyclic structure and lack of flexible side chain structural design. In this work, a flexible ether spaced N-spirocyclic quaternary ammonium functionalized side chain is proposed, in which hydroxyl substituted N-spirocyclic cation provides active grafting site with chloromethylated polysulfone through Williamson etherification. The flexible ether-oxygen spacer promotes aggregation of the rigid spirocyclic cations and thus significantly improves conductivity The uniformly in-situ thermal crosslinking between benzene rings and the residue chloromethyl groups in polysulfone greatly enhances mech. properties of the membranes. Constrained ring conformation of N-spirocyclic cation, ether spaced benzyl-free side chain, as well as the OH- blocking crosslinked networks endow an excellent alk. stability to the membranes. The ether spaced N-spirocyclic containing membranes exhibit well micro-phase separation structure, up to around 85.7 mS cm-1 of hydroxide conductivity at 80°C, around 10.5 MPa of tensile strength in hydrated state and around 95.6% conductivity retention after immersion in 1 M KOH at 80°C for 720 h. The performance is among the best N-spirocyclic functionalized AEMs reported in the literature.

There are many compounds similar to this compound(111-24-0)Category: chiral-nitrogen-ligands. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis